ReviewNaunyn-Schmiedeberg's archives of pharmacology2025
Cuproptosis: the mechanisms of copper-induced cell death and its implication in colorectal cancer.
Review in Naunyn-Schmiedeberg's archives of pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- Subtype-Specific Alterations in Copper Trafficking Associated with KRAS Mutations in Isogenic Colorectal Cancer Cell Lines.Biological trace element research · 2026Article
- Targeting cell death: a promising approach for colorectal cancer therapy.Cancer cell international · 2026Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Colorectal cancer (CRC) represents a prevalent neoplastic disorder of the digestive tract, characterized by elevated incidence and mortality rates. The cellular metabolism of copper within CRC cells is frequently dysregulated, indicating that modifications to copper concentrations may induce cell death and potentially enhance the overall suppression of tumor progression. Cuproptosis, a recently identified form of cellular death, occurs when copper ions bind directly to the lipoylated components of the citric acid cycle (CAC) within mitochondrial respiration, thereby disrupting the balance of iron-sulfur cluster (Fe-S cluster) proteins and ultimately leading to protein toxic stress. The defining traits of cuproptosis include dependence on Cu2
Indexed as
Identifiers
40397118What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.