Value of postmastectomy radiotherapy on overall survival in stage II-III node-negative patients following neoadjuvant therapy: A surveillance, epidemiology, and end results-based population study.

Xiaoyu Wang, Xiaolin Zhao, Pian Cheng, Xiaomeng Zou, Weike Zhang, Jie Liu

Abstract read

In one paragraph

Article in Science progress. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Xiaoyu WangJinan Central Hospital, Shandong Second Medical University, Weifang, China.ORCID 0009-0000-7335-8028

Xiaolin ZhaoJinan Central Hospital, Shandong Second Medical University, Weifang, China.

Pian ChengJinan Central Hospital, Shandong Second Medical University, Weifang, China.

Xiaomeng ZouDepartment of Oncology, Yantai Laiyang Central Hospital, Yantai, China.

Weike ZhangDepartment of Oncology, Central Hospital affiliated to Shandong First Medical University, Jinan, China.

Jie LiuDepartment of Oncology, Central Hospital affiliated to Shandong First Medical University, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The necessity of postmastectomy radiotherapy (PMRT) for patients whose initially positive lymph nodes become node-negative (ypN0) after neoadjuvant therapy (NAT) is uncertain. This study analyzed data from the Surveillance, Epidemiology, and End Results database to evaluate PMRT's effect on these patients. Women with unilateral breast cancer who achieved ypN0 status post-NAT from 2010 to 2019 were categorized into PMRT and non-PMRT groups. Propensity score matching (PSM) minimized confounding factors. Statistical tests and multivariate analysis identified survival prognostic factors, while Kaplan-Meier curves and forest plots assessed survival outcomes. The study involved 699 cases, with 458 receiving PMRT and 241 not. After matching, 194 patient pairs were examined. Multivariate analysis revealed stage III disease (hazard ratio: 2.06; 95% CI: 1.12-3.79,

Indexed as

Breast NeoplasmsMastectomyNeoadjuvant TherapyAdultAgedFemaleHumansKaplan-Meier EstimateMiddle AgedNeoplasm StagingPrognosisRadiotherapy, AdjuvantSEER ProgramBreast cancerneoadjuvant therapypostmastectomy radiotherapySEER databasestage II–III

Identifiers

PMID40397103

DOI10.1177/00368504251344185

PMCPMC12099104

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.