Evidence map›Paper›PMID 40397079›Full record

ArticleJournal of Alzheimer's disease : JAD2025

Association of rare

Akinori Miyashita, Ai Obinata, Norikazu Hara, Risa Mitsumori, Daita Kaneda, Yoshio Hashizume, Terunori Sano, Masaki Takao, Ramil Gabdulkhaev, Mari Tada and 24 more

Abstract read
In one paragraph

Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Akinori MiyashitaDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.ORCID 0000-0003-2508-9649
Ai ObinataDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.ORCID 0009-0009-3813-5043
Norikazu HaraDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.ORCID 0000-0001-8525-3469
Risa MitsumoriMedical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan.ORCID 0009-0000-3383-1327
Daita KanedaDepartment of Neuropathology, Fukushimura Hospital, Toyohashi, Japan.ORCID 0000-0001-9431-8105
Yoshio HashizumeDepartment of Neuropathology, Fukushimura Hospital, Toyohashi, Japan.ORCID 0000-0002-8389-5860
Terunori SanoDepartment of Clinical Laboratory and Internal Medicine, National Center of Neurology and Psychiatry (NCNP), National Center Hospital, Kodaira, Japan.ORCID 0000-0001-8967-5984
Masaki TakaoDepartment of Clinical Laboratory and Internal Medicine, National Center of Neurology and Psychiatry (NCNP), National Center Hospital, Kodaira, Japan.ORCID 0000-0002-5392-996X
Ramil GabdulkhaevDepartment of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.ORCID 0000-0001-6929-2388
Mari TadaDepartment of Pathology Neuroscience, Brain Research Institute, Niigata University, Niigata, Japan.ORCID 0000-0003-1485-0703
Akiyoshi KakitaDepartment of Pathology, Brain Research Institute, Niigata University, Niigata, Japan.ORCID 0000-0003-4244-0277
Akira ArakawaDepartment of Neuropathology (the Brain Bank for Aging Research), Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-ku, Japan.ORCID 0000-0002-9336-1168
Maho MorishimaDepartment of Neuropathology (the Brain Bank for Aging Research), Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-ku, Japan.ORCID 0009-0003-1047-5915
Shigeo MurayamaDepartment of Neuropathology (the Brain Bank for Aging Research), Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-ku, Japan.ORCID 0000-0001-9709-5242
Yuko SaitoDepartment of Neuropathology (the Brain Bank for Aging Research), Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-ku, Japan.ORCID 0000-0002-9974-8638
Hiroyuki HatsutaDepartment of Neurology, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Tomoyasu MatsubaraDepartment of Neuropathology (the Brain Bank for Aging Research), Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi-ku, Japan.ORCID 0000-0002-7559-8284
Akio AkagiDepartment of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan.ORCID 0000-0003-4712-7562
Yuichi RikuDepartment of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan.ORCID 0000-0002-6493-8976
Hiroaki MiyaharaDepartment of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan.ORCID 0000-0003-0723-0047
Jun SoneDepartment of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan.ORCID 0000-0002-9057-7609
Mari YoshidaDepartment of Neuropathology, Institute for Medical Science of Aging, Aichi Medical University, Nagakute, Japan.ORCID 0000-0002-8520-6184
Haruyasu YamaguchiProfessor Emeritus, Gunma University, Maebashi, Japan.
Tamao TsukieDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.
Mai HasegawaDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.ORCID 0000-0001-9234-6014
Kensaku KasugaDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.ORCID 0000-0002-2178-0769
Masataka KikuchiDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.ORCID 0000-0002-9562-841X
Hiroyasu AkatsuCenter for Frailty and Locomotive Syndrome, National Center for Geriatrics and Gerontology, Obu, Japan.ORCID 0000-0002-0089-6033
Ryozo KuwanoSocial Welfare Corporation Asahigawaso, Asahigawaso Research Institute, Okayama, Japan.ORCID 0000-0002-8593-0113
Takeshi IwatsuboDepartment of Neuropathology, Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Japan.ORCID 0000-0003-1160-8129
Japanese Alzheimer's Disease Neuroimaging InitiativeJapanese Alzheimer's Disease Neuroimaging Initiative, Japan.
Shumpei NiidaResearch Institute, National Center for Geriatrics and Gerontology, Obu, Japan.
Kouichi OzakiMedical Genome Center, Research Institute, National Center for Geriatrics and Gerontology, Obu, Japan.ORCID 0000-0003-0028-1570
Takeshi IkeuchiDepartment of Molecular Genetics, Brain Research Institute, Niigata University, Niigata, Japan.ORCID 0000-0001-8828-8085

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BackgroundLittle is known about the rare missense variants (RMVs) of

Indexed as

Alzheimer DiseaseApolipoproteins EGenetic Predisposition to DiseaseMutation, MissenseAgedAged, 80 and overAsian PeopleCase-Control StudiesCohort StudiesEast Asian PeopleFemaleGene FrequencyGenotypeHumansJapanMaleApoE protein, humanApolipoproteins EAlzheimer's diseaseAPOEcholesterolJapaneselipidrare missense variants

Identifiers

PMID40397079
PMCPMC12254517

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.