ArticleJournal of Alzheimer's disease : JAD2025
Psychological impact of biomarker-assisted diagnosis of Alzheimer's disease.
Article in Journal of Alzheimer's disease : JAD, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Short-term psychological impacts of Alzheimer's disease risk disclosure based on blood-biomarker results.Alzheimer's & dementia (New York, N. Y.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BackgroundCerebrospinal fluid biomarkers can be used to diagnose biological Alzheimer's disease (AD). The psychological safety of this approach is often questioned given the paucity of effective therapies for AD.ObjectiveWe wanted to evaluate the psychological impact of biomarker assisted diagnosis on patients and their caregivers.MethodsUsing a mixed method design, 10 patients and 16 caregivers were evaluated before and after receiving a diagnosis of AD with this technique. Interviews were conducted to explore their perspectives. Questionnaires were used to evaluate the effects on quality of life, depression and caregiver burden.ResultsParticipants mentioned themes like having an objective explanation for their symptoms, being able to act on the information, finding lumbar puncture invasive, and receiving a difficult diagnosis with little possible action. Most participants said they would recommend the procedure. Measures of quality of life, depression and caregiver burden were similar before and after disclosure.ConclusionsThis study suggests that, from a psychological perspective, cerebrospinal fluid-based diagnosis of AD could be offered to patients after discussion of potential benefits and risks. Further research is needed in this field, especially as new diagnostic methods become more available.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.