Evidence map›Paper›PMID 40397071›Full record

ArticleBrain structure & function2025

Dynamic inferior olive activation in a cognitive task: an fMRI study.

Annakarina Mundorf, Laura C Rice, Jutta Peterburs, John E Desmond

Abstract read
In one paragraph

Article in Brain structure & function, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Annakarina MundorfDepartment of Neurology, Division of Cognitive Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA. annakarina.mundorf@medicalschool-hamburg.de.ORCID https://orcid.org/0000-0002-3667-5339
Laura C RiceCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, Baltimore, MD, USA.ORCID https://orcid.org/0000-0001-8525-1631
Jutta PeterbursDepartment of Neurology, Division of Cognitive Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0003-3571-126X
John E DesmondDepartment of Neurology, Division of Cognitive Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID https://orcid.org/0000-0002-3113-7363

Funding

Investigation of cerebellar involvement in cognitive sequencingR01MH128278 · NIMH · JOHNS HOPKINS UNIVERSITY · PI JOHN E DESMOND · 2022 to 2026
$3.9M
Investigation of Cerebellar Involvement in Cognitive FunctionR01MH104588 · NIMH · JOHNS HOPKINS UNIVERSITY · PI DESMOND, JOHN E · 2015 to 2020
$2.7M
NIMH NIH HHS R01 MH104588NIMH NIH HHS R01 MH128278
6 · The paper itself

Abstract

The inferior olive provides powerful inputs to the cerebellum hypothesized to support cerebellar learning and error detection. Given cerebellar involvement in verbal working memory and the close interplay with the inferior olive, the inferior olive is likely also involved in verbal working memory. In order to elucidate the inferior olive's role in verbal working memory, we utilized an MRI-based Sternberg verbal working memory task which involved learning novel vs repeated sequences. As hypothesized, inferior olive activation was stronger during encoding and retrieval compared to maintenance, especially for novel compared to repeated sequences, indicative of diminished inferior olive activity with stimulus repetition. Results also revealed differential inferior olive activation during retrieval, with increased activation on matching probes for novel and on non-matching probes for repeated sequences. This underlines the crucial role of the inferior olive in novel information encoding and error feedback, and that conditions triggering strong inferior olive responses can change as a function of novelty.

Indexed as

CognitionMemory, Short-TermOlivary NucleusVerbal LearningAdultBrain MappingFemaleHumansMagnetic Resonance ImagingMaleNeuropsychological TestsYoung AdultBrainstemCognitionError processingPredictionTeaching signals

Identifiers

PMID40397071
PMCPMC12095361

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.