Evidence map›Paper›PMID 40397034›Full record

ArticleMolecular biology reports2025

The MNS blood group system in Tunisian blood donors: common and rare alleles.

Mohamed Hichem Sellami, Eya Ghazouani, Sondess Hadj Fredj, Hamida Ferchichi, Manel Chaabane, Houda Kaabi, Taieb Messaoud, Slama Hmida

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

8 authors.

Mohamed Hichem Sellami"Immunogenetics, Cell Therapy and Blood Transfusion" Research Laboratory (LR20SP05), Department of Immunohaematology, National Blood Transfusion Centre of Tunis, University of Tunis El Manar, 13 Street of Djbel Lakhdar, Bab Saadoun, Tunis, 1006, Tunisia. mohamedhichem.sellami@rns.tn.ORCID https://orcid.org/0000-0002-0527-8760
Eya Ghazouani"Immunogenetics, Cell Therapy and Blood Transfusion" Research Laboratory (LR20SP05), Department of Immunohaematology, National Blood Transfusion Centre of Tunis, University of Tunis El Manar, 13 Street of Djbel Lakhdar, Bab Saadoun, Tunis, 1006, Tunisia.
Sondess Hadj FredjBiochemistry Laboratory, Bechir Hamza Children's Hospital, Bab Saadoun, Tunis, 1007, Tunisia.
Hamida Ferchichi"Immunogenetics, Cell Therapy and Blood Transfusion" Research Laboratory (LR20SP05), Department of Immunohaematology, National Blood Transfusion Centre of Tunis, University of Tunis El Manar, 13 Street of Djbel Lakhdar, Bab Saadoun, Tunis, 1006, Tunisia.
Manel Chaabane"Immunogenetics, Cell Therapy and Blood Transfusion" Research Laboratory (LR20SP05), Department of Immunohaematology, National Blood Transfusion Centre of Tunis, University of Tunis El Manar, 13 Street of Djbel Lakhdar, Bab Saadoun, Tunis, 1006, Tunisia.
Houda Kaabi"Immunogenetics, Cell Therapy and Blood Transfusion" Research Laboratory (LR20SP05), Department of Immunohaematology, National Blood Transfusion Centre of Tunis, University of Tunis El Manar, 13 Street of Djbel Lakhdar, Bab Saadoun, Tunis, 1006, Tunisia.
Taieb MessaoudBiochemistry Laboratory, Bechir Hamza Children's Hospital, Bab Saadoun, Tunis, 1007, Tunisia.
Slama Hmida"Immunogenetics, Cell Therapy and Blood Transfusion" Research Laboratory (LR20SP05), Department of Immunohaematology, National Blood Transfusion Centre of Tunis, University of Tunis El Manar, 13 Street of Djbel Lakhdar, Bab Saadoun, Tunis, 1006, Tunisia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe MNS blood group system is highly complex and characterized by the presence of major polymorphic antigens, namely MNS1/MNS2 and MNS3/MNS4. This study aims to examine the genetic basis of the common MNS antigens in Tunisian blood donors and discussed their importance in transfusion immunology. METHODS AND

resultsA group of 229 Tunisian blood donors were genotyped for the major alleles GYPA*01, GYPA*02, GYPB*03 and GYPB*04 using the SSP-PCR method. A specific GYPA region was sequenced in some subjects to examine if there is a rare allele. The statistical analysis was done using the HaploView Software. The molecular analysis showed that 4 blood donors are probably carrier of a rare GYPA allele. Furthermore, it appeared that the GYPA*01 and GYPB*04 alleles; and the GYPA*01-GYPB*04 haplotype are predominant in this series. As for the phenotype, the study showed that the MNS:1,2,-3,4 type is the most frequent in recruited blood donors.

conclusionsOverall, the study showed a balanced distribution of the targeted alleles. Furthermore, the observed frequencies appeared to be in harmony with that reported in other populations. Considering the importance of these findings, we think that this work will be an important contribution to the field of public health and epidemiology.

Indexed as

Blood DonorsGlycophorinsMNSs Blood-Group SystemAdultAllelesBlood Group AntigensFemaleGene FrequencyGenotypeHaplotypesHumansMaleTunisiaBlood Group AntigensGlycophorinsGYPA protein, humanGYPB protein, humanMNSs Blood-Group SystemAlloimmunizationBloodMNS antigensPCR-SSPTunisians

Identifiers

PMID40397034

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.