Evidence map›Paper›PMID 40396869›Full record

ArticleMemorias do Instituto Oswaldo Cruz2025

Single nucleotide polymorphisms in IFN-gamma, TNF-alpha, IL-6, IL-10, and TGF-beta in pulmonary and extrapulmonary tuberculosis in the State of Ceará, northeastern Brazil.

Roberta Dos Santos Silva Luiz, Thales Alves Campelo, Caroliny Soares Silva, Lucas de Lima Nogueira, Soraya de Oliveira Sancho, Ana Karolliny Alves da Silva, Cristiane Cunha Frota, Filipe Anibal Carvalho-Costa

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Memorias do Instituto Oswaldo Cruz, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Roberta Dos Santos Silva LuizUniversidade Federal do Ceará, Faculdade de Medicina, Laboratório de Micobactérias, Fortaleza, CE, Brasil.
Thales Alves CampeloUniversidade Federal do Ceará, Faculdade de Medicina, Laboratório de Micobactérias, Fortaleza, CE, Brasil.
Caroliny Soares SilvaUniversidade Federal do Ceará, Faculdade de Medicina, Laboratório de Micobactérias, Fortaleza, CE, Brasil.
Lucas de Lima NogueiraUniversidade Federal do Ceará, Faculdade de Medicina, Laboratório de Micobactérias, Fortaleza, CE, Brasil.
Soraya de Oliveira SanchoUniversidade Federal do Ceará, Faculdade de Medicina, Laboratório de Micobactérias, Fortaleza, CE, Brasil.
Ana Karolliny Alves da SilvaUniversidade Federal do Ceará, Faculdade de Medicina, Laboratório de Micobactérias, Fortaleza, CE, Brasil.
Cristiane Cunha FrotaUniversidade Federal do Ceará, Faculdade de Medicina, Laboratório de Micobactérias, Fortaleza, CE, Brasil.
Filipe Anibal Carvalho-CostaFundação Oswaldo Cruz-Fiocruz, Instituto Oswaldo Cruz, Laboratório de Epidemiologia e Sistemática Molecular, Rio de Janeiro, RJ, Brasil.ORCID http://orcid.org/0000-0001-8083-2840

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSingle nucleotide polymorphisms (SNP) in genes encoding cytokines influence tuberculosis (TB) outcomes.

objectivesTo characterise genotypes of the SNPs IFN-gamma +874 T > A, TNF-alpha -308 G > A, IL-6 -174 G > C, IL-10 -1082A > G, TGF-beta codon 10 T > C, and TGF-beta codon 25 G > C in patients with pulmonary (PTB) and extrapulmonary TB (EPTB).

methods82 PTB and 45 EPTB cases were compared, concerning genotype distribution of the mentioned SNPs, characterised via sequence-specific primer polymerase chain reaction (PCR).

findingsRegarding IFN-gamma +874 T > A, AA genotype was the most frequent in both groups, TA was more frequent in PTB and TT in EPTB, with no statistical significance. For SNP TNF-alpha -308 G > A, GG was more frequent in both groups of patients. Regarding the IL-6 -174 G > C polymorphism, GG predominated in both groups, while CG and GG were significantly more frequent in patients with PTB and EPTB, respectively. Concerning IL-10 -1082 A > G, AA predominated in both PTB and EPTB. Concerning TGF-beta codon 10 T > C, CC predominated in PTB while TC predominated in EPTB, but the differences were not statistically significant. Genotype GG of TGF-beta codon 25 G > C predominated among PTB and EPTB patients. MAIN

conclusionsExcept for IL-6, the genotype profile could not differentiate PTB and EPTB. Hence, the studied SNPs are not significantly associated with the extrapulmonary involvement of TB.

Indexed as

Polymorphism, Single NucleotideTransforming Growth Factor betaTuberculosisTuberculosis, PulmonaryAdolescentAdultAgedBrazilFemaleGenotypeHumansInterferon-gammaInterleukin-10Interleukin-6MaleMiddle AgedInterferon-gammaInterleukin-10Interleukin-6Transforming Growth Factor betaTumor Necrosis Factor-alpha

Identifiers

PMID40396869
PMCPMC12084083

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.