Evidence map›Paper›PMID 40396766›Full record

ArticleClinical and translational science2025

The Relationship of Indomethacin Exposure With Efficacy and Renal Toxicity Outcomes for Preterm Infants in the Neonatal Intensive Care Unit.

Cindy H T Yeung, Deanna C Sekulich, Allison Scott, Whitney M Nolte, Kim Gibson, Rachel Su, Mhd Wael Alrifai, Susan M Lopata, Tamorah Lewis, Jeff Reese and 1 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical and translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Cindy H T YeungDivision of Clinical Pharmacology & Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0002-2334-6376
Deanna C SekulichMildred T. Stahlman Division of Neonatology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0009-0001-7920-772X
Allison ScottDivision of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Hospital, Kansas City, Missouri, USA.
Whitney M NolteDivision of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Hospital, Kansas City, Missouri, USA.ORCID 0000-0002-0282-0833
Kim GibsonDivision of Clinical Pharmacology, Toxicology and Therapeutic Innovation, Children's Mercy Hospital, Kansas City, Missouri, USA.
Rachel SuMildred T. Stahlman Division of Neonatology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Mhd Wael AlrifaiMildred T. Stahlman Division of Neonatology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0000-0003-0761-4905
Susan M LopataMildred T. Stahlman Division of Neonatology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.ORCID 0009-0001-9972-9605
Tamorah LewisDivision of Clinical Pharmacology & Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada.ORCID 0000-0003-2137-8339
Jeff ReeseMildred T. Stahlman Division of Neonatology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.
Anil MaharajFaculty of Pharmaceutical Sciences, The University of British Columbia, Vancouver, British Columbia, Canada.

Funding

Pharmacologic Contributors to Patent Ductus ArteriosusR01HL164327 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI REESE, JOHN JEFFREY · 2022 to 2025
$2.9M
NHLBI NIH HHS R01 HL164327
6 · The paper itself

Abstract

Indomethacin is commonly used in the Neonatal Intensive Care Unit (NICU) for intraventricular hemorrhage (IVH) prophylaxis and patent ductus arteriosus (PDA) treatment, yet unpredictable clinical efficacy and toxicity occur with standard weight-based dosing. Model-informed precision dosing (MIPD) produces individualized doses to overcome deficiencies of standard dosing. To identify an indomethacin therapeutic index for MIPD to target, exposure-response relationships (ERRs) were determined. Indomethacin pharmacokinetic and demographic data collected from preterm infants treated at two US NICUs were leveraged. The following ERRs were assessed: (1) AUC

Indexed as

Cerebral Intraventricular HemorrhageDuctus Arteriosus, PatentIndomethacinArea Under CurveDose-Response Relationship, DrugFemaleGestational AgeHumansInfant, NewbornInfant, PrematureIntensive Care Units, NeonatalKidneyMaleRetrospective StudiesTreatment OutcomeIndomethacinadverse drug reactionsefficacyexposure responseneonatalpharmacokinetics–pharmacodynamicspharmacologypopulation pharmacokineticsprecision medicine

Identifiers

PMID40396766
PMCPMC12093495

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.