Evidence map›Paper›PMID 40396760›Full record

ArticleJournal of virology2025

Comparative study on the virulence of mycobacteriophages.

Ilaria Rubino, Carlos A Guerrero-Bustamante, Melissa Harrison, Sheila Co, Isobel Tetreau, Mani Ordoubadi, Sasha E Larsen, Rhea N Coler, Reinhard Vehring, Graham F Hatfull and 1 more

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of virology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Ilaria RubinoDepartment of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0003-1589-1566
Carlos A Guerrero-BustamanteDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-7256-5188
Melissa HarrisonDepartment of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta, Canada.
Sheila CoDepartment of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta, Canada.
Isobel TetreauDepartment of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada.
Mani OrdoubadiDepartment of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada.
Sasha E LarsenSeattle Children's Research Institute, Center for Global Infectious Disease Research, Seattle, Washington, USA.ORCID 0000-0001-5034-9727
Rhea N ColerSeattle Children's Research Institute, Center for Global Infectious Disease Research, Seattle, Washington, USA.
Reinhard VehringDepartment of Mechanical Engineering, University of Alberta, Edmonton, Alberta, Canada.
Graham F HatfullDepartment of Biological Sciences, University of Pittsburgh, Pittsburgh, Pennsylvania, USA.ORCID 0000-0002-6705-6821
Dominic SauvageauDepartment of Chemical and Materials Engineering, University of Alberta, Edmonton, Alberta, Canada.ORCID 0000-0002-1995-5523

Funding

Bacteriophage diversity, dynamics, function, and exploitationR35GM131729 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Graham F. Hatfull · 2019 to 2026
$3.6M
Advancing mycobacteriophage aerosol for prevention of pulmonary infectionsR21AI156807 · NIAID · SEATTLE CHILDREN'S HOSPITAL · PI COLER, RHEA N, LARSEN, SASHA E. · 2021 to 2022
$503k
NIAID NIH HHS R21 AI156807NIGMS NIH HHS R35 GM131729
6 · The paper itself

Abstract

The global tuberculosis (TB) epidemic affected 10 million people and caused 1.3 million deaths in 2022 alone. Multidrug-resistant TB is successfully treated in less than 60% of cases by long, expensive, and aggressive treatments. Mycobacteriophages, viruses that can infect bacteria such as IMPORTANCE: This study provides a systematic investigation of the virulence of three mycobacteriophages, Fionnbharth, Muddy, and D29, and their combinations as cocktails against

Indexed as

MycobacteriophagesMycobacterium smegmatisMycobacterium tuberculosisBiofilmsVirulencebacteriophagesD29Fionnbharthinfection dynamicsMuddymycobacteriophagesMycobacterium smegmatisphage adsorptionphagesvirulencevirulence index

Identifiers

PMID40396760
PMCPMC12172466

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.