Evidence map›Paper›PMID 40396632›Full record

ArticleThe Laryngoscope2025

Impact of WPOI-5 on Risk of Regional Recurrence in Early Oral Cancer With pN0 Neck.

Justin Hintze, Nadia van den Berg, Deirdre Callanan, Shima Mohamed, Linda Feeley, Patrick Sheahan

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PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Justin HintzeDepartment of Otolaryngology, South Infirmary Victoria University Hospital, Cork, Ireland.ORCID 0000-0002-7837-4032
Nadia van den BergDepartment of Otolaryngology, South Infirmary Victoria University Hospital, Cork, Ireland.ORCID 0009-0002-9623-775X
Deirdre CallananDepartment of Otolaryngology, South Infirmary Victoria University Hospital, Cork, Ireland.
Shima MohamedDepartment of Pathology, Cork University Hospital, Cork, Ireland.
Linda FeeleyDepartment of Pathology, Cork University Hospital, Cork, Ireland.
Patrick SheahanDepartment of Otolaryngology, South Infirmary Victoria University Hospital, Cork, Ireland.ORCID 0000-0002-9153-8951

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionRegional recurrence (RR) has been reported to occur in 7%-17% of patients with oral squamous cell carcinoma (OSCC) and pathologically negative (pN0) necks. Risk factors for isolated RR, in the absence of simultaneous local recurrence, are poorly defined. Our aim was to study risk factors for isolated RR in early OSCC with clinically and pathologically negative necks.

methodsRetrospective cohort study of 202 patients with cT1/2N0 OSCC.

resultsAmong 130 patients undergoing elective neck dissection, 98 were pN0. Five (5.1%) developed isolated RR, and 7 (7.1%) developed any RR. Risk factors for isolated RR were worst pattern of invasion category 5 (WPOI-5) (p = 0.02), and absence of postoperative radiotherapy (PORT) (p = 0.04). Among 170 patients with pN0 or cN0/x necks, risk factors for isolated RR were WPOI-5 and depth of invasion > 10 mm. On multivariate analysis, only WPOI-5 remained significant.

conclusionIsolated RR may occur in over 5% of patients with early OSCC and pathologically negative necks after elective ND. WPOI-5 would appear to be the most important risk factor for isolated RR in pN0 cases. Further work is required to define the role of PORT in patients with WPOI-5. LEVEL OF EVIDENCE: 3:

Indexed as

Carcinoma, Squamous CellMouth NeoplasmsNeoplasm Recurrence, LocalAdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedNeck DissectionNeoplasm InvasivenessNeoplasm StagingRetrospective StudiesRisk Factorselective neck dissectionhead and neckneckneck dissectionoral cavitypN0squamous cell carcinomaWPOI‐5

Identifiers

PMID40396632
PMCPMC12371855

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.