Evidence map›Paper›PMID 40396584›Full record

ArticleThe Laryngoscope2025

Characterizing Disease Severity Through Surgical Recurrence Rates in Idiopathic Subglottic Stenosis.

Andrew Jay Bowen, Andrew Awadallah, Monet McCalla, Ariel Roitman, Hawa Ali, Glen Leverson, Yousuf Khalil, Sydney Ring, Eric Edell, Matthew Koster and 6 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Laryngoscope, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Andrew Jay BowenDepartment of Otolaryngology-Head and Neck Surgery, MetroHealth Medical Center, Cleveland, Ohio, USA.ORCID 0000-0002-6542-7932
Andrew AwadallahMayo Clinic Alix School of Medicine, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0001-5574-7388
Monet McCallaDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Ariel RoitmanDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Hawa AliDepartment of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0002-6197-8593
Glen LeversonDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Yousuf KhalilMayo Clinic Alix School of Medicine, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0009-0006-2148-6486
Sydney RingUniversity of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.ORCID 0009-0004-3955-450X
Eric EdellDivision of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota, USA.
Matthew KosterDivision of Rheumatology, Mayo Clinic, Rochester, Minnesota, USA.
Semirra BayanDepartment of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota, USA.
Katherine XieDepartment of Otolaryngology-Head & Neck Surgery, University of Minnesota-Twin Cities, Minneapolis, Minnesota, USA.ORCID 0000-0003-0007-5136
Ruth DavisDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.ORCID 0000-0001-9592-932X
David O FrancisDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.ORCID 0000-0003-1064-5892
Dale EkbomDepartment of Otorhinolaryngology, Mayo Clinic, Rochester, Minnesota, USA.ORCID 0000-0001-8770-8463
Seth H DaileyDivision of Otolaryngology-Head and Neck Surgery, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.ORCID 0000-0002-3299-3014

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThere is currently not a marker of disease severity in idiopathic subglottic stenosis (iSGS). Our objective was to characterize iSGS patients' disease severity using endoscopic surgery rates.

methodsThis was a two-center retrospective analysis of iSGS patients with a minimum of 4 years of follow up following an initial endoscopic procedure (laser wedge excision (LWE) or endoscopic dilation (ED)). Disease severity was classified into Groups A-C, based on whether patients had fewer (Group A), the same number (Group B), or more surgeries (Group C) in years 3-5 compared to years 1 and 2. Disease severity proportions were compared across institutions using chi-square analysis. Nonparametric testing compared clinical characteristics such as age, BMI, and GERD across severity groups.

resultsThere were 104 patients from institution 1 and 53 patients from institution 2 that were all female and predominantly Caucasian. Both institutions had clinically and statistically similar proportions of patients in Group A (64% vs. 62%), Group B (20% vs. 19%), and Group C (16% vs. 19%) disease (p > 0.05). No clinical characteristic (e.g., age, sex, race, BMI, GERD) was associated with disease severity.

conclusionAcross tertiary care institutions there is a consistent proportion of iSGS patients who either demonstrate nonrecurrent/decelerating (Group A), stable but persistent (Group B), or rapidly recurring disease (Group C). Two-year surgery rates appear to be an important timepoint for providing expectations to patients on the likelihood of possessing severe disease. LEVEL OF EVIDENCE: 4:

Indexed as

LaryngoscopyLaryngostenosisAdultAgedFemaleFollow-Up StudiesHumansLaser TherapyMaleMiddle AgedRecurrenceRetrospective StudiesSeverity of Illness Indexendoscopic balloon dilationidiopathic subglottic stenosislaser wedge excisionsteroid injections

Identifiers

PMID40396584
PMCPMC12475557

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.