Evidence map›Paper›PMID 40396443›Full record

ArticleCancer control : journal of the Moffitt Cancer Center

Pain as an Adverse Event During Chemotherapy in Children with Acute Lymphoblastic Leukemia: A Cross-Sectional Nationwide Study.

Fernanda Machado Silva-Rodrigues, Pamela S Hinds, Carlos Alberto Scrideli, Silvia Regina Brandalise, Maria Alessandra Silva Salgado, Lucila Castanheira Nascimento

Abstract read
In one paragraph

Article in Cancer control : journal of the Moffitt Cancer Center. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fernanda Machado Silva-RodriguesDepartment of Maternal-Infant and Psychiatric Nursing, School of Nursing, University of São Paulo, São Paulo - SP, Brazil.ORCID 0000-0002-8412-2333
Pamela S HindsDepartment of Nursing Science, Professional Practice & Quality, Children's National Hospital, Pediatrics at School of Medicine and Health Sciences, George Washington University, Washington, DC, USA.
Carlos Alberto ScrideliPediatrics Department, Ribeirão Preto Medical School, University of São Paulo, Ribeirão Preto, SP, Brazil.ORCID 0000-0001-6618-789X
Silvia Regina BrandaliseDr. Domingos A. Boldrini Children's Center for Hematologic Research, Boldrini Center, Campinas - SP.
Maria Alessandra Silva SalgadoDr. Domingos A. Boldrini Children's Center for Hematologic Research, Boldrini Center, Campinas - SP.
Lucila Castanheira NascimentoDepartment of Maternal-Infant and Public Health Nursing, University of São Paulo at Ribeirão Preto College of Nursing, Ribeirão Preto, SP, Brazil.ORCID 0000-0002-7900-7111

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

IntroductionPain is a common adverse event of chemotherapy in pediatric oncology patients. Understanding pain's impact on these patients is essential for improving their quality of life and treatment outcomes. This short communication aims to describe the characteristics of pain in children with Acute Lymphoblastic Leukemia (ALL) and to explore its interactions with hospitalization duration and relapse, considering variables such as age, gender, and risk level.MethodsThis retrospective study analyzed data from 610 observations of pediatric patients with ALL treated under the Brazilian GBTLI-99 protocol. Pain was recorded according to CTCAE criteria. Statistical analyses, including Chi-square, Mann-Whitney, Poisson, and logistic regression models, were applied to explore associations between pain, hospitalization length, relapse, and other variables.ResultsOur results indicated that patients who presented with pain experienced longer hospitalization lengths. No significant difference in the presence of pain in female or male pediatric patients was observed.ConclusionThis study is a first step towards treating pain as a limiting event that compromises the quality of life and response to treatment in Brazilian pediatric cancer patients.

Indexed as

Antineoplastic Combined Chemotherapy ProtocolsPainPrecursor Cell Lymphoblastic Leukemia-LymphomaAdolescentBrazilChildChild, PreschoolCross-Sectional StudiesFemaleHospitalizationHumansInfantMaleQuality of LifeRetrospective Studiescancerchemotherapychildrenpain

Identifiers

PMID40396443
PMCPMC12099079

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.