Nerve Conduction Study and the Prognosis of Amyotrophic Lateral Sclerosis: Exploration of Additional Neuroelectrophysiological Parameters.

Jie Yang, Feng Xiao, Ying Liu, Jiaying Bai, Song Tan

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Article in European journal of neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 authors.

Jie YangDepartment of Neurology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.ORCID 0000-0002-6833-2680

Feng XiaoDepartment of Neurology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Ying LiuDepartment of Neurology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Jiaying BaiDepartment of Neurology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Song TanDepartment of Neurology, Sichuan Provincial People's Hospital, School of Medicine, University of Electronic Science and Technology of China, Chengdu, China.

Funding

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6 · The paper itself

Abstract

objectiveTo investigate the correlation between nerve conduction study (NCS) parameters and the prognosis of patients with amyotrophic lateral sclerosis (ALS).

methodsNCS parameters were recorded from the median, ulnar, peroneal, tibial, and superficial peroneal nerves of 114 sporadic patients with ALS. The main endpoint was death or tracheostomy. Univariate Cox regression analysis was conducted for all the NCS parameters. Subsequently, multivariate analysis was performed using Cox stepwise regression, incorporating factors identified in the univariate analysis and known prognostic factors. Kaplan-Meier curves and log-rank tests were used for survival analysis. Receiver operating characteristic (ROC) curves were used to assess the predictive capabilities of NCS parameters.

resultsThe distal compound muscle action potential (dCMAP) negative peak area and the sensory nerve action potential (SNAP) amplitude of the median nerve were identified as prognostic factors for ALS. Further stratified analyses showed that larger median dCMAP negative peak area significantly correlated with better prognosis in elderly (> 61 years) patients with limb-onset ALS. Conversely, higher median SNAP amplitudes indicated worse prognosis in younger (≤ 61 years) patients with limb-onset ALS.

conclusionThe current study showed that the dCMAP negative peak area and SNAP amplitude of the median nerve are independent prognostic factors for sporadic ALS patients.

Indexed as

Amyotrophic Lateral SclerosisNeural ConductionAction PotentialsAdultAgedAged, 80 and overFemaleHumansMaleMedian NerveMiddle AgedNerve Conduction StudiesPrognosisamyotrophic lateral sclerosiscox regression analysisKaplan–Meier curvenerve conduction studyprognosis

Identifiers

PMID40396430

DOI10.1111/ene.70209

PMCPMC12093251

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