Trial reportJournal of the American Heart Association2025
Educational Attainment and the Effect of Intensive Blood Pressure Reduction: A Post Hoc Analysis of the SPRINT Study.
Trial report in Journal of the American Heart Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Intensive Blood Pressure Control and Cardiovascular Outcomes Across Cardiovascular-Kidney-Metabolic Syndrome Stages: A Post Hoc Analysis of the China Rural Hypertension Control Project.JAMA network open · 2026Trial
- Orthostatic blood pressure changes among adults in Ekiti state, Nigeria: Impact of socio-demographic, anthropometric, and biophysical factors.Physiological reports · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundHypertension is a major risk factor for cardiovascular disease (CVD). The SPRINT (Systolic Blood Pressure Intervention Trial) study demonstrated that intensive lowering of systolic blood pressure (SBP) targeting <120 mm Hg reduced cardiovascular disease risk and all-cause death among high-risk patients with hypertension. The link between education and cardiovascular health is well documented, but it remains unclear whether the effect of intensive SBP reduction differs by education.
methodsWe included 9361 SPRINT participants, stratified by education (less than college, some college through college graduate, and greater than college degree). We examined the effect of intensive SBP lowering across educational strata in relation to both SBP achieved and the composite cardiovascular SPRINT end point using multivariable proportional hazards models.
resultsParticipants' average age was 67.9±9.4 years, with 35.6% women and 57.8% White race; 24.4% received greater than a college degree and 33.7% had less than a college education. Those with higher education were more likely to be older, men, and White race. During follow-up, SBP was nearly identical across categories of education. Education was associated with a dose-response reduction in the composite end point after intensive SBP lowering, particularly among non-Black individuals (highest to lowest education: adjusted hazard ratios, 0.44 [95% CI, 0.29-0.66]; 0.82 [95% CI, 0.60-1.12]; and 0.88 [95% CI, 0.63-1.22];
conclusionsDespite similar SBP, higher education was associated with a larger improvement in cardiovascular outcomes following intensive SBP reduction, with differences by race. These findings highlight the relevance of social factors such as education in the generalizability of clinical trials.
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