Evidence map›Paper›PMID 40396370›Full record

ArticleNucleic acids research2025

GEPIA3: Enhanced drug sensitivity and interaction network analysis for cancer research.

Yu-Jian Kang, Lingjie Pan, Yiyu Liu, Zhengqin Rong, Jiaxi Liu, Fenglin Liu

Abstract read
In one paragraph

Article in Nucleic acids research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed.

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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yu-Jian KangChongqing Key Laboratory of Intelligent Oncology for Breast Cancer, Cancer Hospital, School of Medicine, Chongqing University, Chongqing 400030, China.
Lingjie PanSchool of Life Sciences, Peking University, Beijing 100871, China.
Yiyu LiuSchool of Life Sciences, Peking University, Beijing 100871, China.
Zhengqin RongWuxi Yiou Biotechnology Co., Ltd., Wuxi 214000, China.
Jiaxi LiuSchool of Life Sciences, Peking University, Beijing 100871, China.
Fenglin LiuSchool of Life Sciences, Peking University, Beijing 100871, China.ORCID 0000-0002-2049-9975

Funding

Fundamental Research Funds for the Central Universities 2024CDJYXTD-010Peking University JG2025013
6 · The paper itself

Abstract

The GEPIA series has provided robust and widely used tools for pan-cancer analysis of gene expression data. In the post-genomic era, a major challenge lies in deconvoluting complex regulatory relationship influenced by multiple factors and discovering gene-based precision therapeutics. Here we present GEPIA3, an advanced version of GEPIA that provides a comprehensive analysis of gene/protein interactions across various cancer types. This version facilitates the investigation of treatment sensitivity utilizing both real-world patient data and cell line screens for over 1000 therapeutic agents, as well as the integration of RNA alterations derived from the pan-cancer analysis of whole genomes project. GEPIA3 represents a significant enhancement of the original platform, enabling in-depth exploration of gene regulation and cancer phenotypes, thereby supporting the identification of novel biomarkers and therapeutic targets. GEPIA3 is publicly accessible at https://gepia3.bioinfoliu.com.

Indexed as

Antineoplastic AgentsGene Regulatory NetworksNeoplasmsSoftwareCell Line, TumorDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticHumansProtein Interaction MapsAntineoplastic Agents

Identifiers

PMID40396370
PMCPMC12230660

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.