Evidence map›Paper›PMID 40396327›Full record

ArticleCombinatorial chemistry & high throughput screening2026

Association of Increased SOAT2 Expression with Abnormal Cholesterol Esterification and Testosterone Deficiency in Late-Onset Hypogonadism Rats.

Min Pan, Ziao Liu, Jingya Li, Xiaohan Ni, Yujia Wang, Lingling Zhang, Tongsheng Wang

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Article in Combinatorial chemistry & high throughput screening, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Min PanPharmacological Department of the College of Integrated Chinese and Western Medicine, Anhui University of Traditional Chinese Medicine, Hefei, China.
Ziao LiuPharmacological Department of the College of Integrated Chinese and Western Medicine, Anhui University of Traditional Chinese Medicine, Hefei, China.
Jingya LiPharmacological Department of the College of Integrated Chinese and Western Medicine, Anhui University of Traditional Chinese Medicine, Hefei, China.
Xiaohan NiPharmacological Department of the College of Integrated Chinese and Western Medicine, Anhui University of Traditional Chinese Medicine, Hefei, China.
Yujia WangBasic Medical College, Hebei Medical University, Shijiazhuang, China.
Lingling ZhangENT Department, The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China.
Tongsheng WangPharmacological Department of the College of Integrated Chinese and Western Medicine, Anhui University of Traditional Chinese Medicine, Hefei, China.

Funding

National Natural Science Foundation of China 82174162Postgraduate Education Quality Project in Anhui Province 2023xscx095
6 · The paper itself

Abstract

backgroundLate-Onset Hypogonadism (LOH) is a prevalent age-related condition in men, characterized by a decline in testosterone (T) and associated symptoms.

objectiveThis study explored the mechanism of T deficiency in LOH.

methodsMale SD rats were raised until 20 months of age in order to establish the LOH models. The hormone level and sperm quality were examined. The behavior experiments were carried out to assess whether LOH rats had anxiety and cognitive dysfunction. RNA-seq was used to explore the differential gene in the testis of LOH rats, revealing the molecular mechanism of LOH.

resultsLOH rats exhibited cognitive impairment and anxiety. The sperm quality was decreased, and dysfunction of the Hypothalamic-Pituitary-Gonadal (HPG) axis was observed in LOH rats. Testosterone biosynthesis enzymes (including StAR, Cyp17A1, and HSD17β) were suppressed, reducing T levels. RNA-seq revealed that cholesterol metabolism and steroid hormone biosynthesis were abnormal. The expression of Sterol O-Acyltransferase 2 (SOAT2) was upregulated in the Leydig cells in the testes of LOH rats. Meanwhile, the testicular Cholesterol Ester (CE) increased, and Free Cholesterol (FC) decreased in the LOH rats. DISCUSSION: These results indicated that upregulation of SOAT2 decreased FC and increased CE, which led to testosterone deficiency and further affected spermatogenesis and the HPG axis.

Indexed as

CholesterolHypogonadismSterol O-AcyltransferaseTestosteroneAnimalsDisease Models, AnimalMaleRatsRats, Sprague-DawleyTestisCholesterolSterol O-AcyltransferaseTestosteronecholesterol esterificationhypothalamic-pituitary-gonadal (HPG) axisLate-onset hypogonadism (LOH)RNA-seqsterol o-acyltransferase 2 (SOAT2)testosterone deficiency

Identifiers

PMID40396327

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.