Evidence map›Paper›PMID 40396313›Full record

ReviewCurrent neuropharmacology2026

The Status and Future Directions of Treatments for Polyglutamine Spinocerebellar Ataxia: A Bibliometric and Visual Analysis.

Siyu Ding, Linliu Peng, Zhao Chen, Mengyuan Dong, Cuiling Tang, Yiqing Gong, Lang He, Qi Wu, Rong Qiu, Hong Jiang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Current neuropharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Siyu DingDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Linliu PengDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Zhao ChenDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Mengyuan DongDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Cuiling TangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Yiqing GongDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Lang HeDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Qi WuDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.
Rong QiuSchool of Computer Science and Engineering, Central South University, Changsha, China.
Hong JiangDepartment of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, China.

Funding

Central South University Research Programme of Advanced Interdisciplinary Study 2023QYJC010Fundamental Research Funds for the Central Universities of Central South University 2024ZZTS0563, 2024ZZTS0028Furong Lab Research Project 2023SK2084Major Scientific Research Project for High-level Health Talent in Hunan Province R2023047National Key R&D Program of China 2021YFA0805200National Natural Science Foundation of China 82171254, 82371272Natural Science Foundation of Hunan Province 2024JJ3050, 2022JJ20094Postdoctoral Fellowship Program of CPSF GZB20230870Science and Technology Innovation Program of Hunan Province 2022RC1027
6 · The paper itself

Abstract

backgroundPolyglutamine (polyQ) spinocerebellar ataxias (SCA) are a group of autosomal dominant neurodegenerative disorders for which no effective treatments currently exist. These conditions impose a significant burden on patients, their families, and society. Consequently, the treatment of these disorders has attracted significant global interest.

objectiveWe conducted this bibliometric analysis to identify the key research hotspots and predict the future research directions of this field.

methodsStudies relating to the treatment of polyQ SCA published from 1999 to 2024 were retrieved from the Web of Science Core Collection database. Relevant papers were selected using predefined inclusion and exclusion criteria. HistCite, VOSviewer, CiteSpace, and alluvial generator were used in the bibliometric analysis.

resultsOverall, 935 papers were included. The number of publications in this field showed a trend toward a fluctuating increase. The United States and the University of Coimbra were the leading countries and institutions, respectively, in terms of publication number. The two most productive and highly cited authors were Luis Pereira de Almeida and Patricia Maciel. The journals

conclusionThis study presents a systematic bibliometric analysis of research on the polyQ SCA treatment, which we hope will assist researchers in identifying the key topics and future research directions in this field.

Indexed as

BibliometricsPeptidesSpinocerebellar AtaxiasAnimalsHumansPeptidespolyglutamineBibliometricsCiteSpacegene therapy.polyglutamate spinocerebellar ataxiatreatmentVOSviewer

Identifiers

PMID40396313
PMCPMC13054738

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.