Evidence map›Paper›PMID 40396180›Full record

ArticleFrontiers in immunology2025

Longitudinal analysis of hsa-miR-3163, hsa-miR-124-3p, hsa-miR-548c-3p, and hsa-miR-27a-3p as prognostic biomarkers in HIV-infected patients.

Ilker Inanç Balkan, Andleeb Shahzadi, Haktan Sönmez, Burhaneddin Oktan, Muhammad Ihtisham Umar, Bilgül Mete, Fehmi Tabak, Günnur Deniz, Umut Can Küçüksezer

Abstract read
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Ilker Inanç Balkan *Department of Immunology, Aziz Sancar Institute of Experimental Medicine, İstanbul University, İstanbul, Türkiye.
Andleeb Shahzadi *Department of Medical Pharmacology, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, İstanbul, Türkiye.
Haktan SönmezDepartment of Medical Pharmacology, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, İstanbul, Türkiye.
Burhaneddin OktanDepartment of Medical Pharmacology, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, İstanbul, Türkiye.
Muhammad Ihtisham UmarDepartment of Pharmacy, COMSATS University Islamabad, Lahore, Pakistan.
Bilgül MeteDepartment of Infectious Diseases and Clinical Microbiology, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, İstanbul, Türkiye.
Fehmi TabakDepartment of Infectious Diseases and Clinical Microbiology, Cerrahpaşa Faculty of Medicine, Istanbul University-Cerrahpaşa, İstanbul, Türkiye.
Günnur DenizDepartment of Immunology, Aziz Sancar Institute of Experimental Medicine, İstanbul University, İstanbul, Türkiye.
Umut Can KüçüksezerDepartment of Immunology, Aziz Sancar Institute of Experimental Medicine, İstanbul University, İstanbul, Türkiye.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: MicroRNAs (miRNAs), key regulators of cellular pathways, play crucial roles in the pathogenesis of various diseases, including Human Immunodeficiency Virus (HIV). This study aimed to evaluate the expression and diagnostic potential of Methods: Blood samples and clinical data of 16 patients were collected at 4 different time points; before the initiation of ART (baseline), 1 Results: miR-27a-3p expression was significantly increased at 2 Discussion: Our findings highlight the potential of miR-3163 as a robust prognostic biomarker for monitoring HIV progression and optimizing ART strategies. Validation in larger cohorts is warranted to confirm its clinical utility.

Indexed as

HIV InfectionsMicroRNAsAdultBiomarkersCD4 Lymphocyte CountFemaleHumansLongitudinal StudiesMaleMiddle AgedPrognosisViral LoadBiomarkersMicroRNAsMIRN124 microRNA, humanMIRN27 microRNA, humanAntiretroviral Therapy (ART)CD4 T-lymphocyte countHuman Immunodeficiency Virus (HIV)MicroRNAs (miRNAs)miR-3163 expressionprognostic biomarkersquantitative RT-PCR (qRT-PCR)

Identifiers

PMID40396180
PMCPMC12089146

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.