Evidence map›Paper›PMID 40396173›Full record

ArticleFrontiers in immunology2025

Osteopontin regulates right ventricular failure through integrin ανβ3/PERK/CHOP-dependent inflammatory and apoptotic pathways.

Xiaomei Yang, Xuyang Wang, Kai Li, Qiming Deng, Yonghao Hou, Guangmin Xi, Kangping Lu, Zihua Liu, Yu Bai, Jianbo Wu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Xiaomei Yang *Department of Anesthesiology, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, China.
Xuyang Wang *Department of Anesthesiology, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, China.
Kai Li *Department of Anesthesiology, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, China.
Qiming DengHypertension Center, Beijing Anzhen Hospital, Capital Medical University, Beijing, China.
Yonghao HouDepartment of Anesthesiology, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, China.
Guangmin XiCollege of Life Science, Qi Lu Normal University, Jinan, Shandong, China.
Kangping LuThe Second Clinical Medical School of Shandong University, Shandong University, Jinan, Shandong, China.
Zihua LiuDepartment of Cardiovascular Surgery, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Yu BaiNational Key Laboratory for Innovation and Transformation of Luobing Theory, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, Jinan, Shandong, China.
Jianbo WuDepartment of Anesthesiology, The First Affiliated Hospital of Shandong First Medical University, Jinan, Shandong, China.
Jingui YuDepartment of Anesthesiology, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, China.
Peng ZhangDepartment of Anesthesiology, Qilu Hospital of Shandong University, Shandong University, Jinan, Shandong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Right ventricular failure is a life-threatening condition commonly associated with obvious immune responses in its progression. This study aims to investigate the role of osteopontin (OPN) in right ventricular failure pathogenesis and evaluate its potential as a therapeutic target. Methods: This study adopted a multi-level design. First, immune-related differentially expressed genes (IRDEGs) were identified using the GEO database (GSE161473) and immune cell composition analysis via ImmuCellAI. A right ventricular failure (RVF) rat model was established, and Western blot, RT-qPCR, and immunohistochemical/immunofluorescence analyses were performed to assess OPN expression and inflammatory infiltration. Results: We found that OPN triggered cardiomyocyte inflammatory responses by activating endoplasmic reticulum stress via the Integrin-ανβ3/PERK/CHOP pathway. OPN exhibited concentration-dependent effects on cardiomyocyte survival: at 2 μg/ml it showed protective effects through BCL-2 modulation, while higher concentrations promoted apoptosis. Importantly, serum OPN levels strongly correlated with NT-proBNP and disease severity in RVF patients. Discussion: These findings identify OPN as a crucial mediator of RVF pathogenesis through the regulation of inflammatory and apoptotic pathways, establishing its potential as a promising therapeutic target.

Indexed as

ApoptosisHeart FailureIntegrin alphaVbeta3OsteopontinTranscription Factor CHOPVentricular Dysfunction, RightAnimalsDisease Models, AnimalEndoplasmic Reticulum StressFemaleHumansInflammationMaleMyocytes, CardiacRatsRats, Sprague-DawleyDDIT3 protein, humanDdit3 protein, ratIntegrin alphaVbeta3OsteopontinTranscription Factor CHOPapoptosisendoplasmic reticulum stressinflammationosteopontinright ventricular failure

Identifiers

PMID40396173
PMCPMC12088963

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.