Evidence map›Paper›PMID 40396031›Full record

ArticleAutophagy reports2022

TFEBexplorer: An integrated tool to study genes regulated by the stress-responsive Transcription Factor EB.

Rossella De Cegli, Diego Carrella, Diletta Siciliano, Gennaro Gambardella, Gennaro Napolitano, Chiara Di Malta, Andrea Ballabio, Diego di Bernardo

Abstract read
In one paragraph

Article in Autophagy reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Rossella De CegliTelethon Institute of Genetics and Medicine (TIGEM), via Campi Flegrei, 34, 80078 Pozzuoli (Naples), Italy.ORCID https://orcid.org/0000-0002-8526-8692
Diego CarrellaTelethon Institute of Genetics and Medicine (TIGEM), via Campi Flegrei, 34, 80078 Pozzuoli (Naples), Italy.
Diletta SicilianoTelethon Institute of Genetics and Medicine (TIGEM), via Campi Flegrei, 34, 80078 Pozzuoli (Naples), Italy.
Gennaro GambardellaTelethon Institute of Genetics and Medicine (TIGEM), via Campi Flegrei, 34, 80078 Pozzuoli (Naples), Italy.ORCID https://orcid.org/0000-0001-7517-1347
Gennaro NapolitanoTelethon Institute of Genetics and Medicine (TIGEM), via Campi Flegrei, 34, 80078 Pozzuoli (Naples), Italy.ORCID https://orcid.org/0000-0002-8615-4654
Chiara Di MaltaTelethon Institute of Genetics and Medicine (TIGEM), via Campi Flegrei, 34, 80078 Pozzuoli (Naples), Italy.ORCID https://orcid.org/0000-0001-6524-4354
Andrea BallabioTelethon Institute of Genetics and Medicine (TIGEM), via Campi Flegrei, 34, 80078 Pozzuoli (Naples), Italy.
Diego di BernardoTelethon Institute of Genetics and Medicine (TIGEM), via Campi Flegrei, 34, 80078 Pozzuoli (Naples), Italy.ORCID https://orcid.org/0000-0002-1911-7407

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

TFEBexplorer is a comprehensive web-tool to study genes modulated by the transcription factor EB (TFEB), a master regulator of lysosomal biogenesis and autophagy, that integrates multiple datasets following genetic perturbation of TFEB with experimentally validated and bioinformatically-predicted binding sites across multiple species. Given one gene, or a set of genes of interest, in input (query), the results are displayed in different panels, each reporting results of experiments or bioinformatic analyses. TFEBdb is a unique resource for those interested in understanding the effect of TFEB on a set of genes of interest. The database offers an intuitive interface and results are displayed in an easy-to-interpret format offering information on the expression changes following inducible over-expression, knock-down and knock-out of TFEB across cell lines and species together with experimentally validated and bioinformatically predicted binding sites in the proximal promoter of the gene(s) of interest. The TFEBdb homepage can be found at http://tfeb.tigem.it.

Indexed as

autophagybinding sitegene expressionlysosomeTFEB

Identifiers

PMID40396031
PMCPMC11864625

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.