ArticleAutophagy reports2022
Autophagy tunes chondrocyte differentiation and joint developmental precision in zebrafish.
Article in Autophagy reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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5 authors.
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Abstract
Cartilage is a crucial component of the developing and functioning skeleton. It establishes a template for bone formation and comprises the articular cartilage for smooth joint movement. It is formed by dedicated matrix-secreting cells (chondrocytes) whose development and survival are negatively affected by disorders of crucial homeostatic and metabolic pathways, and by impaired ER and/or mitochondrial stress responses. As these processes are directly influenced by macroautophagy/autophagy, dysregulation of autophagy control in chondrocytes and their progenitors can contribute to human skeletal disorders, notably osteoarthritis (OA). To understand more about the contributions of autophagy during chondrogenesis, we characterized jaw joint development in a new zebrafish
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