ArticleArchives of medical science : AMS2025
Anticancer activity of sulforaphane against human hepatoblastoma cells involves apoptosis, autophagy and inhibition of β-catenin signaling pathway.
Article in Archives of medical science : AMS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Sulforaphane is an active isothiocyanate and has been reported to exhibit many pharmacological and biological activities including anticancer activity. The current study was undertaken to examine its anticancer activity against human hepatoblastoma. Material and methods: MTT and clonogenic assays were used to assess the antiproliferative effects of sulforaphane. Annexin V/PI staining and immunofluorescence microscopy were used to monitor the induction of apoptosis. GFP-LC3 transfection and fluorescence microscopy were used to investigate the induction of autophagy. Cell migration and invasion were assessed through wound healing and transwell chamber assay. Protein expression was determined by western blot analysis. Results: The results indicated that sulforaphane induced antiproliferative effects on the hepatoblastoma cell lines and exhibited an IC Conclusions: The results indicated that sulforaphane is a potential anticancer agent and may be considered as a lead molecule in the development of hepatoblastoma chemotherapy.
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