ReviewArchives of medical science : AMS2025
Efficacy and safety of apixaban and warfarin in prevention of ischemic stroke: a systematic review and meta-analysis.
Review in Archives of medical science : AMS, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Due to various limitations of warfarin use, non-vitamin K oral anticoagulants have gradually become the first choice for the prevention of ischemic stroke. This article will comprehensively and systematically evaluate the efficacy and safety of apixaban and warfarin in the prevention of ischemic stroke, to provide an evidence-based reference for clinical diagnosis and treatment. Material and methods: A comprehensive search of electronic databases, including PubMed, Embase, Cochrane Library, Web of Science, Clinical Trials, China National Knowledge Infrastructure (CNKI), China Biomedical Literature Database (CBM), and Wanfang Database, was performed, and the cut-off date for all databases was May 31, 2021. We reviewed a large number of studies on apixaban versus warfarin in the prevention of ischemic stroke. We compared the incidence of ischemic stroke, any other thromboembolic events, major bleeding, intracranial hemorrhage, and gastrointestinal hemorrhage. Results: From the initial search of 288 results, the final meta-analysis included 11 studies, comprising 6 retrospective cohort studies, 4 observational studies, and 1 randomized controlled trial, with a total of 240,652 patients. There was no statistically significant difference between apixaban and warfarin in incidence of ischemic stroke (OR = 0.80, 95% CI: (0.56, 1.16), Conclusions: Apixaban has more advantages and a higher safety profile than warfarin, making it worthy of widespread use.
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