ReviewFrontiers in pharmacology2025
Plant polysaccharides influence tumor development based on epigenetics: a review.
Review in Frontiers in pharmacology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
4 citing papers in PubMed.
- The non-scaffold effects of natural polysaccharides in promoting organ regeneration: a review.Journal of biological engineering · 2026Review
- Polysaccharide-based anticancer therapeutics: molecular mechanisms, translational advances, and the road toward precision oncology.Frontiers in pharmacology · 2026Review
- Assessment for cytotoxic properties ofCytotechnology · 2025Article
- From laboratory to clinic: opportunities and challenges of functional food active ingredients in cancer therapy.Frontiers in nutrition · 2025Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Plant polysaccharides have emerged as pivotal epigenetic modulators in oncology, offering multi-target therapeutic potential to address toxicity and drug resistance limitations of conventional therapies. This review integrates evidences from multi-database (PubMed, Web of Science and CNKI, 2010-2025) to elucidate three core epigenetic mechanisms of plant polysaccharides (e.g., Astragalus and Ganoderma lucidum): 1) TET2-mediated DNA demethylation; 2) inhibition of histone-modifying enzymes including JMJD2D; 3) regulation of tumor-suppressive miRNAs such as miR-139-5p. Preclinical studies demonstrate synergistic effects with chemotherapeutics, enhancing antitumor efficacy while reducing toxicity through immune modulation (e.g., H22 murine models) and organ protection (e.g., cisplatin regimens). Bibliometric analyses further uncover emerging roles in tumor microenvironment reprogramming, angiogenesis suppression, and macrophage polarization. These findings establish plant polysaccharides as precision oncology agents bridging molecular mechanisms with clinical translation. Future research should prioritize structural standardization, pharmacokinetic profiling, and combinatorial therapy optimization to accelerate clinical translation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.