Evidence map›Paper›PMID 40395706›Full record

ArticleCureus2025

Can Physical Prehabilitation Reverse Frailty in Elderly Patients Before Spine Surgery? A Case Report.

Regina Knudsen, Nicholas Ma, Keri Ann Markut, Basma Mohamed

Abstract readCase Reports
In one paragraph

Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Regina KnudsenAnesthesiology, University of Florida College of Medicine, Gainesville, USA.
Nicholas MaAnesthesiology, University of Florida College of Medicine, Gainesville, USA.
Keri Ann MarkutOrthopedic Surgery and Sports Medicine, University of Florida College of Medicine, Gainesville, USA.
Basma MohamedAnesthesiology, Duke University, Durham, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Frailty is a syndrome that results from age-associated decline of physiological function and decreased response to stressors. It has been associated with postoperative adverse events in the spine surgery population. Evaluation of frailty in older adults undergoing surgery is becoming increasingly incorporated in the preoperative evaluation due to the growing number of aging patients requiring surgery. However, which optimization strategies should be incorporated into the preoperative plan to improve the patient's overall health and quality of life is unclear. Physical prehabilitation has been evaluated in the spine surgery population. However, prehabilitation before spine surgery has mainly focused on cognitive behavioral therapy and physical exercise to alleviate pain. None of the current studies for prehabilitation in spine surgery addressed the role of physical prehabilitation in reversing frailty in older adults. This case report presents the impact of physical prehabilitation on frailty indices and immediate postoperative outcomes in frail spine surgery patients. We present two patients who participated in a physical prehabilitation program for frail older adults requiring spine surgery. Both patients had significant improvement in their frailty, functional capacity, and overall quality of life, as indicated subjectively by the patients. One patient opted out of surgery due to overall improved functional capacity. In this report, we also highlight the impact of physical prehabilitation on the possibility of reversing frailty. Frailty is a well-known risk factor for postoperative adverse events after spine surgery, and whether to modify this risk factor to improve outcomes is still a question that requires future well-designed research studies. This case report shows that physical prehabilitation is a feasible intervention to reverse or prevent the worsening of frailty in spine surgery patients.

Indexed as

frailtygeriatric medicineoptimizationpatient optimizationphysical prehabilitationspine surgery

Identifiers

PMID40395706
PMCPMC12090665

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.