ArticleFrontiers in neuroscience2025
Electroencephalographic characteristics of transcutaneous auricular vagus nerve stimulation for prolonged disorders of consciousness: a study protocol.
Article in Frontiers in neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Awakening the Vagus: Transcutaneous Auricular Vagus Nerve Stimulation-A Narrative Review.Brain sciences · 2026Review
- Transcutaneous auricular vagus nerve stimulation for disorders of consciousness: a narrative review of neurophysiological mechanisms, clinical evidence, and future directions.Frontiers in human neuroscience · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Increasing evidence indicates that transcutaneous auricular vagus nerve stimulation (taVNS) can promote the recovery of consciousness levels in patients with prolonged disorders of consciousness (pDOC). However, previous clinical studies have shown inconsistent clinical efficacy of taVNS in treating pDOC. This could be because no research has clearly defined the indications for taVNS treatment in patients with pDOC, and patients who were not indicated for taVNS treatment were included. Therefore, screening out the indications for patients with pDOC who are suitable for taVNS treatment is a key scientific issue that requires urgent resolution at present. Methods/design: We aim to incorporate 50 patients with pDOC into this study. All patients will undergo a 4-week taVNS treatment, and 30-min resting electroencephalogram (EEG) and Coma Recovery Scale-Revised (CRS-R) scores of each patient will be collected before and after the treatment. After the 4-week taVNS treatment, the patients will be followed up in the first, third, sixth, and twelfth months after the treatment. The 50 patients with pDOC will be classified into response and non-response groups based on whether their CRS-R scores increase. The differences in the brain power spectrum and functional connectivity of the EEG before enrollment between the two groups will be compared. Discussion: The research objective of this experiment is to screen out the EEG characteristics of patients with pDOC who are suitable for taVNS treatment by using EEG technology, and lay the foundation for the wider application of taVNS in the treatment of patients with pDOC. Clinical trial registration: Identifier ITMCTR2024000734, http://itmctr.ccebtcm.org.cn/.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.