ArticleiScience2025
Inter-host diversity associated with age, sex, and menstrual cycle modulates clinical manifestations in DENV-2 patients.
Article in iScience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
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Authors and funding
10 authors.
Funding
Abstract
Dengue virus (DENV-2) remains a global threat, yet the influence of age, sex, and menstrual status on its epidemiology and genetic diversity is underexplored. We analyzed 2136 hospitalized DENV-2 patients (ages 0-86) using whole-genome sequencing (WGS) to examine how these host factors shape interhost viral diversity and clinical manifestations. Young adult males (19-35 years) had the highest prevalence with sex-based clinical differences where females exhibited severe hematological changes, while males showed increased hepatic injury. Premenopausal females harbored more diverse viral populations, whereas postmenopausal women experienced pronounced platelet depletion. Dengue virus WGS identified 1100336 single nucleotide variants (SNVs) across 2932 genomic positions, with greater viral diversity in adults and females. Significant SNV burdens were observed in the
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