ReviewFrontiers in physiology2025
The musculotendinous interface: insights into development, injury, and recovery for military medical applications.
Review in Frontiers in physiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Aligned multicompartment collagen scaffolds support stratified myoblast and fibroblast behavior for musculotendinous tissue engineering.bioRxiv : the preprint server for biology · 2026Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Musculoskeletal injuries (MSKIs) are a major cause of morbidity and lost duty time for military service members, impacting overall military readiness, with overuse injuries being particularly prevalent among them. Musculotendinous injuries, affecting the musculotendinous unit, are especially problematic due to their long recovery times and limited treatment options. To better understand these injuries, this review delves into the developmental, homeostatic, and structural biology of musculotendinous units, with a focus on the musculotendinous junction (MTJ). Additionally, it explores the biomechanical model of the musculotendinous unit and the complexities of endogenous repair processes for muscle, tendon, and MTJ injuries. Based on these insights, the review discusses promising therapeutic approaches for treating these injuries, such as anabolic agents, metabolic reprogramming, scaffold or cell-based therapies, and physical therapy. These emerging therapies offer potential avenues for accelerating endogenous healing, reducing recovery time, and improving long-term outcomes for musculotendinous injuries. Ultimately, further research in this area could significantly enhance military readiness by mitigating the impact of MSKIs on service members.
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Registered trials
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