Evidence map›Paper›PMID 40395614›Full record

ArticleVirus evolution2025

Ancient origins and global spread of domestic cat hepatitis B virus.

Edmilson F de Oliveira-Filho, Simon Franz Müller, Ianei O Carneiro, Otávio V de Carvalho, Alejandro Alfaro-Alarcón, Sebastian Brünink, Fagner D'ambroso Fernandes, Murilo H Anzolini Cassiano, Celia Pedroso, Felix Lehmann and 11 more

Abstract read
In one paragraph

Article in Virus evolution, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors.

Edmilson F de Oliveira-FilhoInstitute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin 10117, Germany.ORCID https://orcid.org/0000-0002-3771-1565
Simon Franz MüllerLaboklin, Bad Kissing, Bavaria 97688, Germany.
Ianei O CarneiroEscola de Medicina Veterinária, Federal University of Bahia, Salvador, BA 40170-110, Brazil.
Otávio V de CarvalhoDepartamento de Biologia Molecular, Tecsa Laboratory, Belo Horizonte 30110-042, Brazil.
Alejandro Alfaro-AlarcónInstitute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin 10117, Germany.ORCID https://orcid.org/0000-0001-9481-6606
Sebastian BrüninkInstitute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin 10117, Germany.
Fagner D'ambroso FernandesDepartamento de Medicina Veterinária, Federal University of Santa Maria, Santa Maria, RS 97105-900, Brazil.
Murilo H Anzolini CassianoInstitute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin 10117, Germany.ORCID https://orcid.org/0000-0001-7123-3985
Celia PedrosoEscola de Medicina Veterinária, Federal University of Bahia, Salvador, BA 40170-110, Brazil.
Felix LehmannInstitute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin 10117, Germany.ORCID https://orcid.org/0000-0002-0259-0062
Wendy K JoInstitute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin 10117, Germany.ORCID https://orcid.org/0000-0003-1253-9540
Andrés Moreira-SotoInstitute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin 10117, Germany.ORCID https://orcid.org/0000-0002-9224-5157
Carlos BritesHospital Universitário Professor Edgard Santos, Federal University of Bahia, Salvador 40110-100, Brazil.ORCID https://orcid.org/0000-0002-4673-6991
Eduardo M NettoHospital Universitário Professor Edgard Santos, Federal University of Bahia, Salvador 40110-100, Brazil.
Luiz E RistowDepartamento de Biologia Molecular, Tecsa Laboratory, Belo Horizonte 30110-042, Brazil.
Rita de Cassia Carvalho MaiaDepartmento de Medicina Veterinária, Federal Rural University of Pernambuco, Recife, PE 52171-900, Brazil.
Fernanda S Flores VogelDepartamento de Medicina Veterinária, Federal University of Santa Maria, Santa Maria, RS 97105-900, Brazil.
Nadia R de AlmeidaEscola de Medicina Veterinária, Federal University of Bahia, Salvador, BA 40170-110, Brazil.
Elisabeth MüllerLaboklin, Bad Kissing, Bavaria 97688, Germany.
Carlos R FrankeEscola de Medicina Veterinária, Federal University of Bahia, Salvador, BA 40170-110, Brazil.
Jan Felix DrexlerInstitute of Virology, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin 10117, Germany.ORCID https://orcid.org/0000-0002-3509-0232

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mammalian hepadnaviruses have likely been evolving alongside their hosts for millions of years. Domestic cat HBV (DCHBV) has been detected in cats from several countries, but its genealogy, epidemiology, and host range remain unclear. Besides DCHBV, the only hepadnavirus identified among carnivores is the ringtail HBV (RtHBV). Because there is a gap in the felid fossil record of approximately 5-7 million years between the late Oligocene and the early Miocene, carnivore-derived viruses might help to shed light on Felidae evolution. Here, we screened 2260 sera and 154 paraffin-embedded liver samples from cats and 2123 sera from dogs sampled in Europe and South and Central America between 2018 and 2020 by PCR for DCHBV. We identified DCHBV genotype A (GtA) in 0.6% (7/1,195; 95% CI, 0.2-1.2) of cats sampled in Germany, France, Croatia, and Bulgaria and a genetically divergent DCHBV genotype B (GtB; 10.8% genomic sequence distance) in 0.2% of cats (2/1,065; 95% CI, 0.0-0.7) from Brazil. The detection rates of the two genotypes did not differ significantly (Fisher,

Indexed as

animal modelscarnivoreshepatitis bneotropicsviral evolution

Identifiers

PMID40395614
PMCPMC12091157

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.