Evidence map›Paper›PMID 40395559›Full record

ArticleQRB discovery2025

Insights on the effect of macromolecular crowding on transcription and its regulation.

Wenxuan Xu, Dylan Collette, Jin Qian, Laura Finzi, David Dunlap

Abstract read
In one paragraph

Article in QRB discovery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. MACRO-MOLECULAR CROWDING FAVORS WRITHE IN UNWOUND DNA.bioRxiv : the preprint server for biology · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Wenxuan XuPhysics Department, Emory University, Atlanta, GA, USA.
Dylan CollettePhysics Department, Emory University, Atlanta, GA, USA.
Jin QianPhysics Department, Emory University, Atlanta, GA, USA.
Laura FinziPhysics Department, Emory University, Atlanta, GA, USA.ORCID https://orcid.org/0000-0003-1173-5339
David DunlapPhysics Department, Emory University, Atlanta, GA, USA.

Funding

Macromolecular Crowding effects on DNA mechanics, topology and transcriptionR35GM149296 · NIGMS · EMORY UNIVERSITY · PI Laura Finzi · 2023 to 2026
$1.5M
NIGMS NIH HHS R35 GM149296
6 · The paper itself

Abstract

Transcription of DNA into RNA is a fundamental cellular process upon which life depends. It is tightly regulated in several different ways, and among the most important mechanisms are protein-induced topological changes in DNA such as looping.

Indexed as

DNA looping and transcriptionMacromolecular crowdingmagnetic tweezerstethered particle motion technique (TPM)Transcription recycling

Identifiers

PMID40395559
PMCPMC12088913

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.