Evidence map›Paper›PMID 40395510›Full record

ArticleFrontiers in cellular and infection microbiology2025

Hepatitis E virus infection and renal injury in non-immunocompromised host: clinical investigation and rabbit model study.

Weigang Zhang, Qiyu He, Hao Wang, Wanyun Gong, Lei Qin, Yunjie Lu, Yuting Wang, Wei Chen, Ling Wang, Wei He and 2 more

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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Weigang Zhang *Department of General Surgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Qiyu He *Department of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Hao Wang *Department of General Surgery, Children's Hospital of Nanjing Medical University, Nanjing, China.
Wanyun GongDepartment of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Lei QinDepartment of General Surgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Yunjie LuDepartment of General Surgery, First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.
Yuting WangDepartment of Infectious Diseases, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu, China.
Wei ChenDepartment of Infectious Diseases, Kunshan First People's Hospital Affiliated to Jiangsu University, Kunshan, Jiangsu, China.
Ling WangDepartment of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Wei HeDepartment of General Surgery, Wujin Affiliated Hospital of Jiangsu University and Wujin Clinical College of Xuzhou Medical University, Changzhou, Jiangsu, China.
Lin WangDepartment of Microbiology and Infectious Disease Center, School of Basic Medical Sciences, Peking University Health Science Center, Beijing, China.
Yu WangDepartment of Hepatobiliary Surgery, Jintan Affiliated Hospital of Jiangsu University, Changzhou, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hepatitis E virus (HEV)-associated renal injury is mainly reported in immunocompromised patients. Here we investigated HEV-associated renal injury in non-immunocompromised acute hepatitis E (AHE) patients and rabbits. Methods: A total of 35 non-immunocompromised AHE patients were tested for kidney function parameters and HEV markers. HEV3- and HEV4-infected rabbits were tested for alanine aminotransferase, creatinine (Cr), and HEV markers. HEV-associated renal injury and renal HEV replication were analyzed by histopathology and RT-qPCR. Results: The non-immunocompromised AHE patients all showed normal serum Cr, blood urea nitrogen (BUN), and urine acid (UA). However, 25% of non-immunocompromised AHE patients showed proteinuria. In the rabbit model, HEV replication was observed in kidney tissues. The HEV-infected rabbits showed a transient elevated Cr level. Renal injury, including focal lymphocytic infiltration and tubular protein casts, was observed in rabbits across acute, recovery, and chronic phases of HEV infection. Conclusions: Proteinuria is not uncommon in non-immunocompromised AHE patients, indicating that HEV infection affects the kidney. We further proved that HEV can cause renal injury in a rabbit model.

Indexed as

Hepatitis EHepatitis E virusKidneyAlanine TransaminaseAnimalsBiomarkersCreatinineDisease Models, AnimalFemaleHumansMaleProteinuriaRabbitsVirus ReplicationAlanine TransaminaseBiomarkersCreatinineclinical investigationhepatitis EHEV (hepatitis E virus)kidneyrabbit model

Identifiers

PMID40395510
PMCPMC12089041

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.