Evidence map›Paper›PMID 40395500›Full record

ArticleFrontiers in computational neuroscience2025

Computational analysis of learning in young and ageing brains.

Jayani Hewavitharana, Kathleen Steinhofel, Karl Peter Giese, Carolina Moretti Ierardi, Amida Anand

Abstract read
In one paragraph

Article in Frontiers in computational neuroscience, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Jayani HewavitharanaDepartment of Informatics, King's College London, London, United Kingdom.
Kathleen SteinhofelDepartment of Informatics, King's College London, London, United Kingdom.
Karl Peter GieseDepartment of Basic and Clinical Neuroscience, King's College London, London, United Kingdom.
Carolina Moretti IerardiDepartment of Neuroimaging, King's College London, London, United Kingdom.
Amida AnandDepartment of Physics, King's College London, London, United Kingdom.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Learning and memory are fundamental processes of the brain which are essential for acquiring and storing information. However, with ageing the brain undergoes significant changes leading to age-related cognitive decline. Although there are numerous studies on computational models and approaches which aim to mimic the learning process of the brain, they often concentrate on generic neural function exhibiting the potential need for models that address age-related changes in learning. In this paper, we present a computational analysis focusing on the differences in learning between young and old brains. Using a bipartite graph as an artificial neural network to model the synaptic connections, we simulate the learning processes of young and older brains by applying distinct biologically inspired synaptic weight update rules. Our results demonstrate the quicker learning ability of young brains compared to older ones, consistent with biological observations. Our model effectively mimics the fundamental mechanisms of the brain related to the speed of learning and reveals key insights on memory consolidation.

Indexed as

ageing-brainscomputational-neurosciencelearningmemoryneural networks

Identifiers

PMID40395500
PMCPMC12089124

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.