ArticleJournal of clinical and translational science2025
Advancing research translation in addiction and pain: A portfolio analysis of the NIH HEAL initiative.
Article in Journal of clinical and translational science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
5 citing papers in PubMed.
- Building bridges, breaking silos: a social network analysis of collaboration in an implementation science center for addiction health services.Translational behavioral medicine · 2026Article
- Knowledge Engineering for Open Science: Building and Deploying Knowledge Bases for Metadata Standards.AI magazine · 2026Article
- Shaping science: Scholarly motivation and research outcomes in NIH-HEAL funded studies.PloS one · 2026Article
- Dissemination and diffusion of research to address the opioid crisis in justice settings: a Justice Community Opioid Innovation Network (JCOIN) case study.Research square · 2025Article
- Engagement, Dissemination, and Implementation: A Review of the Correctional Health Studies funded by the National Institute of Health's HEAL Initiatives.Victims & offenders · 2025Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
Abstract
Background: To date, the NIH Helping to End Addiction Long-term (HEAL) Initiative has funded over 1,000 projects that aim to identify new therapeutic targets for pain and substance use disorder (SUD), develop nonpharmacological strategies for pain management, and improve overdose and addiction treatment across settings. This study conducted a portfolio analysis of HEAL's research to assess opportunities to advance translation and implementation. Methods: HEAL projects (FY 2018-2022) were classified into early (T0-T1) and later (T2-T4) translational stages. Eleven coders used a 54-item data collection tool based on the Consolidated Framework for Implementation Research (CFIR) to extract project characteristics (e.g., population, research setting) relevant to translation and implementation. Descriptive statistics and visualization techniques were employed to analyze and map aggregate characteristics onto CFIR's domains (e.g., outer setting). Results: HEAL's portfolio comprised 923 projects (33.7% T0-T1; 67.3% T2-T4), ranging from basic science (27.1%) and preclinical research (21.4%) to clinical (36.8%), implementation (27.1%), and dissemination research (13.1%). Most projects primarily addressed either addiction (46.3%) or pain (37.4%). Implementation-related gaps included the underrepresentation of certain populations (e.g., sexual/gender minorities: 0.5%). T0-T1 projects occurred primarily in laboratory settings (35.1%), while T2-T4 projects were concentrated in healthcare settings (e.g., hospitals: 21.6%) with limited transferability to other contexts (e.g., community: 12.9%). Conclusion: Opportunities to advance translational and implementation efforts include fostering interdisciplinary collaboration, prioritizing underserved populations, engaging with community leaders and policy stakeholders, and targeting evidence-based practices in nonclinical settings. Ongoing analyses can guide strategic investments to maximize HEAL's impact on substance use and pain crises.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.