Evidence map›Paper›PMID 40395339›Full record

ArticleSmall science2025

Multifunctional Magnetic Ionic Liquid-Carbon Nanohorn Complexes for Targeted Cancer Theranostics.

Yun Qi, Eijiro Miyako

Abstract read
In one paragraph

Article in Small science, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yun QiGraduate School of Advanced Science and Technology Japan Advanced Institute of Science and Technology 1-1 Asahidai, Nomi Ishikawa 923-1292 Japan.
Eijiro MiyakoGraduate School of Advanced Science and Technology Japan Advanced Institute of Science and Technology 1-1 Asahidai, Nomi Ishikawa 923-1292 Japan.ORCID https://orcid.org/0000-0002-1157-6174

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Establishing a rational and simplified design for nanoparticles that selectively target and eliminate cancer cells is a crucial aspect of cancer treatment. In this study, a new multifunctional nanocomplex is developed based on a photoexothermic carbon nanohorn comprising the magnetic and anticancer ionic liquids 1-butyl-3-methylimidazolium tetrachloroferrate and fluorescent indocyanine green, synthesized through a convenient sonication process. The synthesized nanocomplexes exhibit unique therapeutic, photothermal, magnetic, and fluorescent properties, enabling chemotherapeutic, light-, and magnetic-field-driven cancer theranostics. Furthermore, this nanocomplex demonstrates prolonged water-dispersing stability (7 days), high photothermal conversion efficiency (63%), and remarkable stability under biologically permeable near-infrared laser irradiation. Simple magnetic guidance significantly enhances the accumulation of nanocomplexes at tumor sites, facilitating targeted delivery. In vitro and in vivo studies have demonstrated potent anticancer efficacy, high selective cytotoxicity against cancer cells, and minimal impact on normal tissues. This study represents the first application of magnetic ionic liquids in cancer treatment and provides a valuable platform for advanced nanotheranostics.

Indexed as

cancercarbon nanohornionic liquidnanoparticletheranostics

Identifiers

PMID40395339
PMCPMC12087772

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.