Evidence map›Paper›PMID 40395336›Full record

ArticleFrontiers in oncology2025

Influence of age and sex on the diagnostic accuracy of pleural fluid carcinoembryonic antigen for malignant pleural effusion: a

Dan-Ni Yang, Jian-Xun Wen, Yan Niu, Ling Hai, Qian Yang, Su-Na Cha, Cheng Yan, Hong-Zhe Zhu, Ting-Wang Jiang, Li Yan and 5 more

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In one paragraph

Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

Who cites it

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Dan-Ni Yang *Department of Laboratory Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Jian-Xun Wen *Medical Experiment Center, the College of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.
Yan NiuMedical Experiment Center, the College of Basic Medicine, Inner Mongolia Medical University, Hohhot, China.
Ling HaiDepartment of Pathology, the College of Basic Medical, Inner Mongolia Medical University, Hohhot, China.
Qian YangDepartment of Laboratory Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Su-Na ChaDepartment of Laboratory Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Cheng YanDepartment of Laboratory Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Hong-Zhe ZhuDepartment of Laboratory Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Ting-Wang JiangDepartment of Key Laboratory, the Changshu Hospital of Nantong University, Changshu, China.
Li YanDepartment of Respiratory and Critical Care Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Jin-Hong HuangDepartment of Respiratory and Critical Care Medicine, the Changshu Hospital of Nantong University, Changshu, China.
Hong ChenDepartment of Respiratory and Critical Care Medicine, the Changshu Hospital of Nantong University, Changshu, China.
Xin-Ru ZuoInner Mongolia Medical University, Hohhot, China.
Wen-Qi ZhengDepartment of Laboratory Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Zhi-De HuDepartment of Laboratory Medicine, the Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The diagnostic value of pleural fluid carcinoembryonic antigen (CEA) for malignant pleural effusion (MPE) has been well recognized. However, whether age and sex affect its diagnostic accuracy remains unknown. This study aimed to investigate the influence of age and sex on the accuracy of CEA for differentiating MPE and benign pleural effusion (BPE). Methods: We enrolled participants from a prospective cohort (SIMPLE) and a retrospective cohort (BUFF). All participants were patients with pleural effusion with undetermined causes. The clinical characteristics were extracted from the medical records of participants. The area under receiver operating characteristics (ROC) curve (AUC) was used to estimate the diagnostic accuracy of CEA. The effects of sex and age on the diagnostic accuracy of CEA for MPE were analyzed using subgroup analysis. A method characterized by resampling participants with different upper limits was also used to investigate the effect of age. Results: The SIMPLE cohort included 210 participants (91 patients with MPE and 119 patients with BPE), and the BUFF cohort included 235 participants (50 patients with MPE and 185 patients with BPE). Sex did not significantly affect the diagnostic accuracy of CEA. Subgroup analyses with both cohorts revealed the decreased AUC in older patients. The resampling method revealed decreased AUC with the advancement of age. Conclusions: Age should be considered when interpreting the diagnostic accuracy of pleural fluid CEA for MPE, while the effects of sex can be ignored.

Indexed as

agecarcinoembryonic antigen (CEA)malignant pleural effusion (MPE)pleural fluidsex

Identifiers

PMID40395336
PMCPMC12089140

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