ReviewFrontiers in oncology2025
Unraveling the multifaceted roles of extracellular vesicles in bladder cancer: diagnostic insights and therapeutic opportunities.
Review in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
4 citing papers in PubMed.
- Urinary Extracellular Vesicles for High-Precision Bladder Cancer Subtyping and Prognosis.Journal of extracellular biology · 2026Article
- Decoding the role of exosomes in bladder cancer: focusing on tumor progression and immune microenvironment modulation.Frontiers in oncology · 2026Review
- Urinary extracellular vesicles for high-precision bladder cancer subtyping and prognosis.medRxiv : the preprint server for health sciences · 2025Article
- Advances in the role of extracellular vesicles in circulating microRNA biomarker discovery for lung cancer.Frontiers in cell and developmental biology · 2025Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bladder cancer, predominantly urothelial carcinoma, is a global health issue with increasing incidences and mortality. It poses significant diagnostic and therapeutic challenges due to its molecular heterogeneity and the limitations of current detection methods. Extracellular vesicles (EVs), including exosomes, play a crucial role in intercellular communication and have emerged as potential biomarkers and therapeutic agents in bladder cancer. This review focuses on the multifaceted roles of EVs in bladder cancer biology, their potential as diagnostic biomarkers, and their use in therapeutic strategies. We discuss how EVs reflect molecular subtypes of bladder cancer, participate in metabolic reprogramming and angiogenesis, and modulate cellular behavior. The review also highlights the advances in proteomic analysis of urinary and tissue-exudative EVs, identifying specific proteins and RNAs that could serve as non-invasive diagnostic markers. Furthermore, we explore the innovative use of EVs as natural nanocarriers for drug delivery in bladder cancer treatment, demonstrating their potential to enhance the efficacy of chemotherapy and selectively target cancer cells. The integration of EV-based diagnostics with traditional methods could lead to more personalized and effective bladder cancer management, emphasizing the need for further research and clinical validation.
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Registered trials
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