ArticleFrontiers in oncology2025
Impact of clinical trial participation on the survival of patients with newly diagnosed advanced ovarian cancer.
Article in Frontiers in oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
6 authors.
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Abstract
Background: Clinical trials provide access to novel treatments that may offer survival benefits to ovarian cancer patients. This study investigates whether clinical trial participation is associated with improved survival in newly diagnosed advanced ovarian cancer. Methods: We retrospectively investigated patients treated for advanced ovarian cancer at Yonsei Cancer Hospital between 2019 and 2021. During this period, the standard of care included cytoreductive surgery with platinum-based chemotherapy, with or without bevacizumab, followed by maintenance therapy with PARP inhibitors or bevacizumab. This study included 202 patients with stage III-IV, 82 participated in clinical trials [DUO-O (Bevacizumab+immunotherapy (IO)+/- PARP inhibitors), KEYLYNK-001 (PARP inhibitors +IO), ATHENA (PARP inhibitors), TRU-D (IO+IO)] and 120 received standard-of-care. Result: The median follow-up duration was 39.8 months. Disease recurrence occurred in 123 (60.9%) patients and 45 (22.3%) patients died. Among the patients in both groups, there were no significant differences in age, histologic type, stage, median CA-125 level, comorbidities, and Conclusion: Clinical trial participation was associated with improved survival compared with standard of care in patients with newly diagnosed advanced ovarian cancer.
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