ArticleAutophagy reports2023
Cargo-interacting regions (CIR) of CCPG1 capture ER luminal cargos for reticulophagy.
Article in Autophagy reports, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Endoplasmic reticulum autophagy in inflammatory diseases.Frontiers in immunology · 2026Review
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The endoplasmic reticulum (ER) is an organelle that regulates several vital processes necessary to maintain the health of eukaryotic cells. Protein quality control systems selectively remove abnormal ER luminal proteins to maintain ER function. In addition to the ubiquitin-proteasome pathway, the lysosome-dependent selective type of autophagy, reticulophagy (or ER-phagy), plays a crucial role in ER proteostasis. Despite the identification of several reticulophagy receptors, the mechanisms by which cytoplasmic reticulophagy machinery recognizes luminal cargo remain largely unknown. We reported that the reticulophagy receptor CCPG1 (cell cycle progression 1) contains several cargo-interacting regions (CIRs) in its ER luminal region that can directly recognize ER luminal cargos. Our findings suggest that CCPG1 is a key player in sequestering ER luminal cargo into the autophagosome using CIRs.
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Registered trials
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