ArticleCureus2025
Pattern of Deficient Mismatch Repair (dMMR)/ High Microsatellite Instability (MSI-H) Testing in India: A Questionnaire-Based Study.
Article in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Microsatellite instability combined with PD-L1 expression in prognosis of gastric cancer: an integrated analysis based on individual patient data.Frontiers in oncology · 2026Pooled it
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Deficient mismatch repair (dMMR) and high microsatellite instability (MSI-H) constitute a unique phenotype within solid tumors, particularly colorectal, endometrial, and gastric cancer. They offer prognostic significance and serve as a predictor for responses to immunotherapy. The current study aimed to understand the practices, attitudes, and barriers associated with dMMR/MSI-H testing among medical oncologists in India. Methods This study was a cross-sectional survey utilizing a questionnaire, where Indian oncologists were selected through a convenience sampling method. A structured questionnaire consisting of 20 questions was developed, capturing comprehensive information on practices, preferences, and challenges faced by doctors during dMMR/MSI-H testing. A descriptive analysis was performed on the compiled data. Results A significant proportion of doctors (n=35, 62.5%) indicated a general preference for incorporating dMMR/MSI-H testing into their clinical practice. More than half of them believed that positive test results would be observed in 5-15% of patients with metastatic and non-metastatic colon and endometrial tumors. Immunohistochemistry (IHC) emerged as the preferred testing method, with 84% of oncologists usually conducting it as the first test. The issues of affordability and the subsequent awareness among oncologists emerged as a major barrier to the adoption of polymerase chain reaction (PCR) and next-generation sequencing (NGS) techniques for assessing MSI status. The vast majority (89%) agreed with the importance of detecting MSI status when assessing suitability for treatment with PD-1/PD-L1 inhibitors in solid tumor patients. Conclusions A deeper understanding of the importance of dMMR/MSI-H status in the clinical characteristics and prognosis of solid tumors, especially colorectal, gastroesophageal, and endometrial cancers, may lead to increased adoption of dMMR/MSI-H testing and guide the development of more effective therapies.
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