Evidence map›Paper›PMID 40395225›Full record

ArticleMechanobiology in medicine2024

David Gothard, Michael Rotherham, Emma L Smith, Janos M Kanczler, James Henstock, Julia A Wells, Carol A Roberts, Omar Qutachi, Heather Peto, Hassan Rashidi and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Mechanobiology in medicine, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

David GothardBone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, UK.
Michael RotherhamInstitute for Science and Technology in Medicine, Keele University, Guy Hilton Research Centre, Stoke-on-Trent, ST4 7BQ, UK.
Emma L SmithBone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, UK.
Janos M KanczlerBone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, UK.
James HenstockInstitute for Science and Technology in Medicine, Keele University, Guy Hilton Research Centre, Stoke-on-Trent, ST4 7BQ, UK.
Julia A WellsBone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, UK.
Carol A RobertsBone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, UK.
Omar QutachiWolfson Centre for Stem Cells, Tissue Engineering and Modelling, University of Nottingham, Centre for Biomolecular Sciences, University Park, Nottingham, NG7 2RD, UK.
Heather PetoWolfson Centre for Stem Cells, Tissue Engineering and Modelling, University of Nottingham, Centre for Biomolecular Sciences, University Park, Nottingham, NG7 2RD, UK.
Hassan RashidiWolfson Centre for Stem Cells, Tissue Engineering and Modelling, University of Nottingham, Centre for Biomolecular Sciences, University Park, Nottingham, NG7 2RD, UK.
Luis RojoDepartment of Materials, Imperial College London, Royal School of Mines, London, SW7 2AZ, UK.
Lisa J WhiteNottingham Biodiscovery Institute, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK.
Molly M StevensDepartment of Materials, Imperial College London, Royal School of Mines, London, SW7 2AZ, UK.
Alicia J El HajInstitute for Science and Technology in Medicine, Keele University, Guy Hilton Research Centre, Stoke-on-Trent, ST4 7BQ, UK.
Felicity R A J RoseNottingham Biodiscovery Institute, School of Pharmacy, University of Nottingham, Nottingham, NG7 2RD, UK.
Richard O C OreffoBone and Joint Research Group, Centre for Human Development, Stem Cells and Regeneration, Institute of Developmental Sciences, University of Southampton, Southampton, SO16 6YD, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone tissue engineering requires a combination of materials, cells, growth factors and mechanical cues to recapitulate bone formation. In this study we evaluated hybrid hydrogels for minimally invasive bone formation by combining biomaterials with skeletal stem cells and staged release of growth factors together with mechanotransduction. Hybrid hydrogels consisting of alginate and decellularized, demineralised bone extracellular matrix (ALG/ECM) were seeded with Stro-1+ human bone marrow stromal cells (HBMSCs). Dual combinations of growth factors within staged-release polylactic-co-glycolic acid (PLGA) microparticles were added to hydrogels to mimic, in part, the signalling events in bone regeneration: VEGF, TGF-β

Indexed as

Bone ECMBone formationControlled releaseGrowth factorsMechanotransductionSkeletal stem cell

Identifiers

PMID40395225
PMCPMC12082137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.