Evidence map›Paper›PMID 40395191›Full record

ArticleArthritis & rheumatology (Hoboken, N.J.)2025

Regulatory Role of FGL-1 in Interorgan Communication by Controlling T Cell Homeostasis During the Onset of Sjögren Disease.

Kunihiro Otsuka, Aya Ushio, Ruka Nagao, Shigefumi Matsuzawa, Rieko Arakaki, Kazuki Fukuta, Yasuhiro Mouri, Takaaki Tsunematsu, Naozumi Ishimaru

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis & rheumatology (Hoboken, N.J.), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Kunihiro OtsukaDepartment of Oral Pathology, Tokushima University Graduate School of Biomedical Sciences and Department of Interdisciplinary Researches for Medicine and Photonics, Institute of Post-LED Photonics, Tokushima University, Tokushima, Japan.
Aya UshioDepartment of Oral Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan, and Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.
Ruka NagaoDepartment of Oral Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Shigefumi MatsuzawaDepartment of Oral Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan, and Section of Oral and Maxillofacial Surgery, Division of Maxillofacial Diagnostic and Surgical Sciences, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
Rieko ArakakiDepartment of Oral Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Kazuki FukutaDepartment of Oral Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Yasuhiro MouriDepartment of Oral Bioscience, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Takaaki TsunematsuDepartment of Oral Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Naozumi IshimaruDepartment of Oral Pathology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan, and Department of Oral Pathology, Graduate School of Medical and Dental Sciences, Institute of Science Tokyo, Tokyo, Japan.

Funding

JSPS KAKENHI grants #18K19648JSPS KAKENHI grants #21J13008JSPS KAKENHI grants #21K19605JSPS KAKENHI grants #23H00438
6 · The paper itself

Abstract

objectiveAutoimmunity occurs due to the tactics between pathogenic and regulatory factors in systemic organs. Although interorgan communication has been demonstrated in various diseases, the effects of the crosstalk between the immune system and other organs on autoimmune disease is unknown.

methodsWe analyzed the influence of interorgan communication on the cellular or molecular mechanism of autoimmunity using a mouse model of primary Sjögren disease (pSjD) and patients with pSjD by integrative genomic, bioinformatic, pathologic, and immunologic analyses.

resultsFibrinogen-like protein-1 (FGL-1) was identified as a potent factor for interorgan communication between the liver and immune system in pSjD model mice. The production of FGL-1 of the liver is induced by interleukin-6 (IL-6) from CD4

conclusionFGL-1 plays a key role in the onset of autoimmunity by suppressing T cell activation in pSjD. Our results will facilitate the development of novel diagnostic or therapeutic strategies targeting the interorgan communication for autoimmune diseases.

Indexed as

AutoimmunityCD4-Positive T-LymphocytesFibrinogenHomeostasisLiverSjogren's SyndromeT-LymphocytesAnimalsDisease Models, AnimalFemaleHumansInterleukin-6MaleMiceMiddle AgedFibrinogenInterleukin-6

Identifiers

PMID40395191
PMCPMC12569741

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.