Evidence map›Paper›PMID 40395118›Full record

ArticleChemMedChem2025

Synthesis and

Marie M Le Roy, Patricia Le Saëc, Michel Chérel, Alain Faivre-Chauvet, Thibault Troadec, Raphaël Tripier

Abstract read
In one paragraph

Article in ChemMedChem, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Marie M Le RoyUniv. Brest, UMR CNRS 6521 CEMCA, 6 avenue Le Gorgeu, 29200, Brest, France.ORCID https://orcid.org/0000-0003-1063-4050
Patricia Le SaëcUniv. Angers, Nantes Univ., Inserm, CNRS, CRCI2NA, CHU Nantes, F-44007, Nantes, France.ORCID https://orcid.org/0000-0002-6380-6306
Michel ChérelUniv. Angers, Nantes Univ., Inserm, CNRS, CRCI2NA, CHU Nantes, F-44007, Nantes, France.ORCID https://orcid.org/0000-0001-6347-6848
Alain Faivre-ChauvetUniv. Angers, Nantes Univ., Inserm, CNRS, CRCI2NA, CHU Nantes, F-44007, Nantes, France.ORCID https://orcid.org/0000-0003-3849-0087
Thibault TroadecUniv. Brest, UMR CNRS 6521 CEMCA, 6 avenue Le Gorgeu, 29200, Brest, France.ORCID https://orcid.org/0000-0002-8005-4302
Raphaël TripierUniv. Brest, UMR CNRS 6521 CEMCA, 6 avenue Le Gorgeu, 29200, Brest, France.ORCID https://orcid.org/0000-0001-9364-788X

Funding

French National Agency for Research "Investissements d'Avenir" IRONLabexno.ANR-11-LABX-0018-01;IGOLabexno.ANR-11-LABX-0016-01;ArronaxPlusEquipexno.ANR-11-EQPX-0004.Ligue Contre le Cancer CSIRGO2020NExT initiative "Nantes Excellence Trajectory" call for I-SITE projects"Programme d'Investissements d'Avenir (PIA2)" referenceANR-16-IDEX-0007.Région Bretagne - Ligue contre le Cancer IMAGE'INSIRIC ILIAD Nantes-Angers-INCA-DGOS-Inserm 12558 grant
6 · The paper itself

Abstract

CXCR4 is a transmembrane receptor overexpressed in a large variety of cancer cells. In addition to classical antibody- and peptide-targeting for the development of positron emission tomography (PET) radiopharmaceuticals, this receptor possesses a range of small organic inhibitors that can be exploited. These are based mainly on nitrogen-rich scaffolds, such as AMD070, and cyclic polyamines, such as cyclam, in the AMD3100 skeleton. The latter has been explored as a direct

Indexed as

Copper RadioisotopesHeterocyclic CompoundsRadiopharmaceuticalsReceptors, CXCR4BenzylaminesChelating AgentsCyclamsHumansMolecular StructurePositron-Emission TomographyBenzylaminesChelating AgentsCopper-64Copper RadioisotopesCXCR4 protein, humanCyclamsHeterocyclic CompoundsplerixaforRadiopharmaceuticalsReceptors, CXCR4chelatorscoordinationcopper‐64CXCR4positron emission tomography imaging

Identifiers

PMID40395118
PMCPMC12321274

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.