Evidence map›Paper›PMID 40395050›Full record

ArticleMagnetic resonance in medicine2025

Development and optimization of human deuterium MR spectroscopic imaging at 3 T in the abdomen.

Mary A McLean, Ines Horvat Menih, Pascal Wodtke, Joshua D Kaggie, Jonathan R Birchall, Rolf F Schulte, Ashley Grimmer, Elizabeth Latimer, Marta Wylot, Maria J Zamora Morales and 6 more

Abstract read
In one paragraph

Article in Magnetic resonance in medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Assessment of TMagma (New York, N.Y.) · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Mary A McLeanDepartment of Radiology, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0002-3752-0179
Ines Horvat MenihDepartment of Radiology, University of Cambridge, Cambridge, UK.
Pascal WodtkeDepartment of Radiology, University of Cambridge, Cambridge, UK.
Joshua D KaggieDepartment of Radiology, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0001-6706-3442
Jonathan R BirchallDepartment of Radiology, University of Cambridge, Cambridge, UK.ORCID https://orcid.org/0000-0003-3920-4038
Rolf F SchulteGE HealthCare, Munich, Germany.
Ashley GrimmerDepartment of Radiology, University of Cambridge, Cambridge, UK.
Elizabeth LatimerDepartment of Radiology, University of Cambridge, Cambridge, UK.
Marta WylotDepartment of Radiology, University of Cambridge, Cambridge, UK.
Maria J Zamora MoralesDepartment of Radiology, University of Cambridge, Cambridge, UK.
Alixander S KhanDepartment of Radiology, University of Cambridge, Cambridge, UK.
Huanjun WangDepartment of Radiology, University of Cambridge, Cambridge, UK.
James ArmitageCancer Research UK Cambridge Centre, Cambridge, UK.
Thomas J MitchellCancer Research UK Cambridge Centre, Cambridge, UK.
Grant D StewartCancer Research UK Cambridge Centre, Cambridge, UK.
Ferdia A GallagherDepartment of Radiology, University of Cambridge, Cambridge, UK.

Funding

Cambridge Experimental Cancer Medicine Centre ECMCQQR-2022/100003Cancer Research UK C19212/A27150Cancer Research UK C22479/A28667Cancer Research UK EDDPMA-May22/100068Cancer Research UK Cambridge Centre CTRQQR-2021∖100012Gates Cambridge Trust OPP1144NIHR Cambridge Biomedical Research Centre BRC-1215-20014
6 · The paper itself

Abstract

purposeTo establish and optimize abdominal deuterium MR spectroscopic imaging in conjunction with orally administered

methodsA flexible transmit-receive surface coil was used to image naturally abundant deuterium signal in phantoms and healthy volunteers and after orally administered

resultsWater and lipid peaks were fitted with high confidence from both unlocalized spectra and from voxels within the liver, kidney, and spleen on spectroscopic imaging. Artifacts were minimal, despite the high

conclusionWe have shown the feasibility of abdominal deuterium MR spectroscopic imaging at 3 T using a flexible surface coil. Water measurements were obtained in healthy volunteers, and images were acquired in a patient with a renal tumor after drinking

Indexed as

AbdomenDeuteriumKidney NeoplasmsMagnetic Resonance ImagingAdultEquipment DesignFemaleHumansMagnetic Resonance SpectroscopyMalePhantoms, ImagingReproducibility of ResultsSensitivity and SpecificityDeuteriumdeuterium metabolic imagingheavy waterkidneylivermetabolismoncocytoma

Identifiers

PMID40395050
PMCPMC12309867

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.