Evidence map›Paper›PMID 40394950›Full record

ReviewInsect science2026

Signaling pathways in Drosophila testis niche: Local signals that regulate stem cell fate.

Ting Zhao, Xiao-Qiang Yu

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Insect science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Ting ZhaoGuangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, China.
Xiao-Qiang YuGuangdong Provincial Key Laboratory of Insect Developmental Biology and Applied Technology, Guangzhou Key Laboratory of Insect Development Regulation and Application Research, Institute of Insect Science and Technology, School of Life Sciences, South China Normal University, Guangzhou, China.ORCID https://orcid.org/0000-0003-1419-9009

Funding

China Postdoctoral Science Foundation 2024M750976National Natural Science Foundation of China 32372616
6 · The paper itself

Abstract

Stem cells are located in a well-structured and specialized microenvironment called the niche. The niche provides signaling molecules to control the survival, self-renewal, and differentiation of stem cells. As tissues generally contain different types of stem cells, it is important to understand how these stem cells are coordinately regulated by various signaling pathways. The Drosophila testis niche serves as an excellent model for studying such processes, because it harbors 2 types of stem cells, germline stem cells and somatic cyst stem cells. In this review, we summarize the roles of key signaling pathways in stem cell maintenance and differentiation in the Drosophila testis.

Indexed as

DrosophilaSignal TransductionStem Cell NicheStem CellsTestisAnimalsCell DifferentiationMaleBMPDrosophilaHedgehogJAK/STATstem cellstestis

Identifiers

PMID40394950
PMCPMC13441016

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.