Evidence map›Paper›PMID 40394903›Full record

Trial reportMaternal & child nutrition2025

Micronutrient Powders Combined With Malaria Chemoprevention to Improve Anaemia and Cognitive Function in Early Childhood in Mali: A Cluster-Randomised Trial.

Niélé H Diarra, Yahia Dicko, Natalie Roschnik, Modibo Bamadio, Michael Boivin, Yvonne Griffiths, Rebecca Jones, Sham Lal, Helen Moestue, Hamidou Niangaly and 9 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Maternal & child nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors.

Niélé H DiarraSave the Children International, Bamako, Mali.ORCID 0009-0006-1394-5320
Yahia DickoSave the Children International, Bamako, Mali.
Natalie RoschnikSave the Children Federation Inc., Washington, District of Columbia, USA.ORCID 0000-0002-1642-6546
Modibo BamadioSave the Children International, Bamako, Mali.
Michael BoivinDepartment of Psychiatry and Department of Neurology and Ophtalmology, Michigan State University, East Lansing, Michigan, USA.ORCID 0000-0002-0097-1777
Yvonne GriffithsSchool of Education, University of Leeds, Leeds, UK.ORCID 0000-0002-2086-4696
Rebecca JonesUniversity College London, London, UK.
Sham LalFaculty of Infectious Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0002-3650-1398
Helen MoestueSave the Children Federation Inc., Washington, District of Columbia, USA.ORCID 0000-0002-0610-7656
Hamidou NiangalyMalaria Research and Training Center, University of Sciences, Techniques and Technologies, Bamako, Mali.ORCID 0000-0002-9427-0241
Lauren PisaniSave the Children Federation Inc., Washington, District of Columbia, USA.
Renion SayeInstitut National de Recherche en Santé Publique, Ministère de la Santé et du Développement Social, Bamako, Mali.ORCID 0000-0002-4659-4655
Kalifa SidibeSave the Children International, Bamako, Mali.
Karla SmutsFaculty of Infectious Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.
Nia-An Philippe TheraSave the Children International, Bamako, Mali.
Josselin ThuilliezCentre d'Economie de la Sorbonne, CNRS - Universite Paris 1, Paris, France.ORCID 0000-0001-5392-0917
Hans VerhoefDivision Human Health and Nutrition, Wageningen University, Wageningen, The Netherlands.ORCID 0000-0002-9346-9689
Moussa SackoInstitut National de Recherche en Santé Publique, Ministère de la Santé et du Développement Social, Bamako, Mali.
Siân E ClarkeFaculty of Infectious Tropical Diseases, London School of Hygiene and Tropical Medicine, London, UK.ORCID 0000-0002-3829-9584

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A cluster-randomised controlled trial was conducted in 60 communities in southern Mali to evaluate the impact of micronutrient powders (MNP) combined with seasonal malaria chemoprevention (SMC) on anaemia (primary endpoint), Plasmodium infection, stunting and cognitive function in children < 5 years. The 60 communities were randomly allocated to the intervention or control arm, and cross-sectional biomedical and cognitive surveys were conducted after 1 and 3 years in a random sample of 3 and 5 years olds (1052 and 1081 children, respectively). All children aged 3-59 m in intervention and control communities received two rounds of SMC each year during the peak malaria season, and in intervention communities, all children aged 6-59 m additionally received 4 months of daily MNP after the peak malaria season. Despite a high baseline prevalence of anaemia and good fidelity to intervention, this trial found no evidence of impact on study outcomes. The prevalence of anaemia was similar in both arms for both age groups after 1 and 3 years of intervention-after 3 years, the prevalence of anaemia amongst 3-year olds was 57.6% in the intervention arm versus 60.1% in the control group (p = 0.352). For 5-year olds, it was 51.3% and 53.0%, respectively (p = 0.607). No effect was observed on stunting or cognitive function either.

Indexed as

AnemiaAntimalarialsCognitionMalariaMicronutrientsChemopreventionChild, PreschoolCross-Sectional StudiesDietary SupplementsFemaleGrowth DisordersHumansInfantMaleMaliPowdersAntimalarialsMicronutrientsPowdersanaemiachemopreventionchild developmentcognitiondietary supplementsfortificationmalariamicronutrientspowders

Identifiers

PMID40394903
PMCPMC12454176

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.