Evidence map›Paper›PMID 40394891›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2025

Choroid plexus free-water correlates with glymphatic function in Alzheimer's disease.

Xiaomeng Xu, Xinyuan Yang, Junfang Zhang, Yan Wang, Magdy Selim, Yingting Zheng, Ruinan Shen, Lipeng Sun, Qi Huang, Wenjing Wang and 7 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05623124 (Neurovascular Coupling and Digital Biomarkers in Alzheimer's Disease), which is not on this map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05623124 recruitingnot on this map

Neurovascular Coupling and Digital Biomarkers in Alzheimer's Disease

TypeobservationalSponsorRuijin HospitalRan2021 to 2025Enrolled400ConditionsDementiaArmsNo intervention
3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
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  4. Review
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  8. Review
  9. Article
  10. Article
  11. Free water changes and their correlations with multimodal biomarkers in frontotemporal dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
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  18. Choroid plexus free-water correlates with glymphatic function in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xiaomeng XuDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-1717-538X
Xinyuan YangDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Junfang ZhangDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yan WangDepartment of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Magdy SelimStroke Division, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
Yingting ZhengDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ruinan ShenDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lipeng SunDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qi HuangDepartment of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Wenjing WangDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Wei XuDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yihui GuanDepartment of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Jun LiuDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yulei DengDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Fang XieDepartment of Nuclear Medicine and PET Center, Huashan Hospital, Fudan University, Shanghai, China.
Binyin LiDepartment of Neurology and Institute of Neurology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-7903-2149
Alzheimer's Disease Neuroimaging Initiative (ADNI)

Funding

National Natural Science Foundation of China 81901180National Natural Science Foundation of China 82171473National Natural Science Foundation of China 82271441Shanghai Rising-Star Program 21QA1405800STI2030-Major Projects 2022ZD0213800
6 · The paper itself

Abstract

introductionFree-water imaging of the choroid plexus (CP) may improve the evaluation of Alzheimer's disease (AD).

methodsOur study investigated the role of free-water fraction (FWf) of CP in AD among 216 participants (133 Aβ+ participants and 83 Aβ- controls) enrolled in the NeuroBank-Dementia cohort at Ruijin Hospital (RJNB-D). The Alzheimer's Disease Neuroimaging Initiative dataset was used for external validation.

resultsAt baseline, Aβ+ participants showed higher CP FWf, increased white matter hyperintensity (WMH) volume, and decreased diffusion tensor image analysis along the perivascular space (DTI-ALPS). In Aβ+ participants, DTI-ALPS mediated the association between CP FWf and periventricular WMH. CP FWf was associated with cortical tau accumulation, synaptic loss, hippocampal and cortical atrophy, and cognitive performance. During follow-up, CP FWf increased faster in Aβ+ participants than controls. DISCUSSION: Elevated CP FWf indicated impaired glymphatic function and AD neurodegeneration, and can be a sensitive biomarker for AD progression. The study was registered on ClinicalTrials.gov (NCT05623124). HIGHLIGHTS: This cohort study found higher free-water fraction (FWf) of the choroid plexus (CP) in amyloid beta (Aβ)+ participants. CP FWf was related to glymphatic function, brain atrophy, tau burden, synaptic loss, and cognition. Aβ+ participants showed faster growth of CP FWf than Aβ- controls during follow-up. The growth rate of CP FWf exceeded that of white matter lesion and tau accumulation in Aβ+ participants. CP FWf can serve as a sensitive imaging marker of glymphatic function and Alzheimer's disease progression.

Indexed as

Alzheimer DiseaseChoroid PlexusGlymphatic SystemAgedAged, 80 and overAmyloid beta-PeptidesCohort StudiesDiffusion Tensor ImagingFemaleHumansMaletau ProteinsWaterWhite MatterAmyloid beta-Peptidestau ProteinsWaterAlzheimer's diseasechoroid plexusdiffusion tensor image analysis along the perivascular spacefree‐water mappingwhite matter hyperintensity

Identifiers

PMID40394891
PMCPMC12092370

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.