Evidence map›Paper›PMID 40394888›Full record

ReviewWiley interdisciplinary reviews. Nanomedicine and nanobiotechnology

Islet Transplantation: Microencapsulation, Nanoencapsulation, and Hypoimmune Engineering.

Kyungsene Lee, Ana Aviles Vargas, Rita Bottino, Yong Wang

Abstract readReview
In one paragraph

Review in Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kyungsene LeeDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania, USA.
Ana Aviles VargasDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania, USA.
Rita BottinoImagine Pharma, Pittsburgh, Pennsylvania, USA.
Yong WangDepartment of Biomedical Engineering, The Pennsylvania State University, University Park, Pennsylvania, USA.ORCID 0000-0002-2244-1742

Funding

Molecularly regulated release of angiogenic factors from superporous hydrogelsR01HL122311 · NHLBI · PENNSYLVANIA STATE UNIVERSITY, THE · PI WANG, YONG · 2015 to 2023
$4.2M
Three-dimensional One-step Aptamer Selection in the Non-fouling Macroporous HydrogelR01GM154105 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI Yong Wang, Na Xiong · 2024 to 2026
$1.4M
Non-covalent functionalization of collagen for growth factor delivery using bispecific aptamersR01EB035568 · NIBIB · PENNSYLVANIA STATE UNIVERSITY, THE · PI Yong Wang · 2024 to 2026
$1.3M
NHLBI NIH HHS R01 HL122311NIBIB NIH HHS R01 EB035568NIGMS NIH HHS R01 GM154105NIH HHS EB035568NIH HHS GM154105NIH HHS HL122311
6 · The paper itself

Abstract

Islet transplantation represents a promising curative approach for type 1 diabetes by restoring glucose-responsive insulin secretion. However, the requirement for lifelong immunosuppression to prevent immune rejection can lead to significant side effects. Emerging strategies such as microencapsulation, nanoencapsulation, and hypoimmune engineering are being developed to protect transplanted islets from immune attack, thereby enhancing their viability and function. This review critically examines these innovative technologies, highlighting the methodologies, materials, experimental and clinical outcomes, as well as the challenges they face and potential solutions to overcome those challenges.

Indexed as

Islets of Langerhans TransplantationAnimalsDiabetes Mellitus, Type 1Humanscell encapsulationhypoimmune engineeringislet transplantationtype 1 diabetes

Identifiers

PMID40394888
PMCPMC12093044

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.