SynthesisInternational endodontic journal2025
Effectiveness of calcium hydroxide compared to hydraulic calcium silicate cements for direct pulp capping in managing deep caries in vital permanent teeth: A systematic review and meta-analysis.
Synthesis in International endodontic journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
7 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Deep caries management: EFCD-ESE-ORCA S3-level clinical practice guideline.Clinical oral investigations · 2026Guideline
- Deep Caries Management: EFCD-ESE-ORCA S3-Level Clinical Practice Guideline.Caries research · 2026Guideline
- Effectiveness of calcium hydroxide compared to hydraulic calcium silicate cements for direct pulp capping in managing deep caries in vital permanent teeth: A systematic review and meta-analysis.International endodontic journal · 2025Pooled it
- Final-year dental students' self-perceived knowledge and self-reported clinical approaches to vital pulp therapy: a single-institution cross-sectional survey.BMC medical education · 2026Article
- Dentists' Knowledge and Clinical Preferences Regarding Evidence-Based Restorative Material Selection in Türkiye: Implications for Clinical Practice and Healthcare Policy.Healthcare (Basel, Switzerland) · 2026Article
- Serum oxidative stress biomarkers (MDA, SOD, GSH-PX) and IL-6/TNF-α ratio as biochemical indicators of disease progression in pediatric cariogenic pulpitis.Journal of medical biochemistry · 2026Article
- Decision-ready evidence for vital pulp therapy: a network meta-analysis of bioactive materials in mature permanent teeth.Frontiers in dental medicine · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDirect pulp capping (DPC) is the least minimal approach for maintaining pulp vitality after pulp exposure. Besides calcium hydroxide (CaOH), hydraulic calcium silicate cements (HCSC) have increasingly been used for DPC.
objectivesDuring the S3 level guideline development for material choice in DPC, we conducted a systematic review and meta-analysis of existing literature comparing CaOH and HCSC for DPC on permanent teeth. We aimed (1) to assess clinical and radiographic outcomes and (2) patient-reported outcomes of DPC.
methodThree databases from 1 January 1990 to 19 February 2025 (MEDLINE via PubMed, EMBASE and Cochrane Database of Systematic Reviews). Prospective comparative clinical studies comparing CaOH to HCSC for DPC in permanent teeth with healthy or reversibly inflamed pulps were included. Studies on primary teeth or teeth indicative of irreversible pulpitis, teeth with unclear diagnoses or pulp exposure of non-cariogenic origin were excluded. The risk of bias and certainty of evidence were evaluated using the GRADE approach. Using the effect sizes and standard errors for every study, pairwise meta-analysis was performed comparing CaOH and different subgroups of HCSC. Success was defined as the absence of any clinical symptoms (e.g. pain, swelling) and any radiographical signs of an apical lesion. Patient-reported outcomes were additionally sought after.
resultsFive randomized-controlled trials including 552 teeth with an overall moderate certainty of evidence were included. HCSC showed a significantly higher probability of success compared to CaOH (Odds Ratio (OR): 2.68, 95% confidence interval [1.7, 4.22], I
conclusionHCSC showed significantly higher probability for clinical and radiographic success than CaOH. This finding comes with moderate certainty. The impact of material choice on postoperative pain remains unclear. Future clinical studies should include patient-reported outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.