Evidence map›Paper›PMID 40394863›Full record

ArticleJournal of diabetes2025

Sleep Phenotypes, Genetic Susceptibility, and Risk of Obesity in Patients With Type 2 Diabetes: A National Prospective Cohort Study.

Lei Xi, Li Li, Songbo Fu, Yuancheng Dai, Juan Shi, Yanmei Yu, Ying Peng, Hongmei Qiu, Jinsong Kuang, Hongyun Lu and 33 more

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Article in Journal of diabetes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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43 authors.

Lei XiDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0002-1277-0841
Li LiDepartment of Endocrinology, The First Affiliated Hospital of Ningbo University, Ningbo, China.
Songbo FuDepartment of Endocrinology, The First Hospital of Lanzhou University, Lanzhou, China.ORCID https://orcid.org/0009-0006-8856-0978
Yuancheng DaiDepartment of Internal Medicine of Traditional Chinese Medicine, Sheyang Diabetes Hospital, Yancheng, China.
Juan ShiDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0003-2652-8084
Yanmei YuDepartment of Endocrinology, Mudanjiang Cardiovascular Hospital, Mudanjiang, China.
Ying PengDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0003-1069-7000
Hongmei QiuDepartment of Endocrinology and Metabolism, People's Hospital of Yuxi City (The Sixth Affiliated Hospital of Kunming Medical University), Yuxi, China.
Jinsong KuangDepartment of Endocrinology and Metabolism, Shenyang Fourth People Hospital, Shenyang, China.
Hongyun LuDepartment of Endocrinology and Metabolism, Zhuhai Clinical Medical College Affiliated With Jinan University, Zhuhai People's Hospital, Zhuhai, China.
Huige ShaoDepartment of Endocrinology, Changsha Central Hospital, Changsha, China.
Chunlei YuanDepartment of Endocrinology, Shandong Health Zibo Hospital, Zibo, China.
Xiaohu WangDepartment of Endocrinology and Metabolism, Anyang People's Hospital, Anyang, China.ORCID https://orcid.org/0000-0003-0197-3106
Ping ZhangDepartment of Endocrinology, The First People's Hospital of YuLin, Yulin, China.
Sheli LiDepartment of Endocrinology and Metabolism, Yan'an University Affiliated Hospital, Yan'an, China.
Yanhui PanDepartment of Endocrinology, Qixia City People's Hospital, Qixia, China.
Ling HuDepartment of Endocrinology, The Third Affiliated Hospital of Nanchang University (The First Hospital of Nanchang), Nanchang, China.
Zhigang ZhaoDepartment of Endocrinology, Yihe Hospital, Zhengzhou, China.
Yunxia ChenDepartment of Endocrinology and Metabolism, Cangzhou People's Hospital, Cangzhou, China.
Jian KuangDepartment of Endocrinology, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China.
Yi ShuDepartment of Endocrinology, The Sixth Affiliated Hospital, School of Medicine, South China University of Technology, Foshan, China.
Jinhua QianDepartment of Endocrine and Metabolic Diseases, The People's Hospital of Pizhou, Pizhou, China.
Qibin MaoDepartment of Endocrinology and Metabolism, Shaoxing Second Hospital, Shaoxing, China.
Jieji ZhangDepartment of Endocrinology, Fenghua District Traditional Chinese Medicine Hospital of Ningbo, Ningbo, China.
Yan LiuDepartment of Endocrinology, The Third People's Hospital of Datong, Datong, China.ORCID https://orcid.org/0009-0007-4149-1036
Hong YangDepartment of Endocrinology, Ruian People's Hospital, Ruian, China.
Zhaoli YanDepartment of Endocrinology, The Affiliated Hospital of Inner Mongolia Medical University, Hohhot, China.
Weici XieDepartment of Endocrinology, The No. 1 General Hospital in Tian Men, Tianmen, China.
Qian ZhangDepartment of Endocrinology, The Second Affiliated Hospital of Guizhou Medical University, Kaili, China.
Ping ZhangDepartment of Endocrinology, The Second Affiliated Hospital of Dalian Medical University, Dalian, China.
Hongji WuDepartment of Endocrinology, People's Hospital of Putuo District, Zhoushan, China.
Ling GaoDepartment of Endocrinology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, China.
Yongjun JinDepartment of Endocrinology and Metabolism, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China.
Ning XuDepartment of Endocrinology, The First People's Hospital of Lianyungang, Lianyungang, China.
Chaoyang XuDepartment of Endocrinology, Jiangsu Shengze Hospital, Suzhou, China.
Xiaohui SunDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhimin FengDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Qing ZhangDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Lin LiDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Guang NingDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Yifei ZhangDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0003-0272-0602
Yanan CaoDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0002-3848-7040
Weiqing WangDepartment of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, National Clinical Research Center for Metabolic Diseases (Shanghai), Ruijin Yangtze River Delta Health Institute, Research Unit of Clinical and Basic Research on Metabolic Diseases of Chinese Academy of Medical Sciences, Wuxi Branch of Ruijin Hospital, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID https://orcid.org/0000-0001-6027-3084

Funding

CAMS Innovation Fund for Medical Sciences 2020-12M-5-002Capacity building for multidisciplinary cooperation in diagnosis and treatment of major metabolic diseases Z155080000004Chinese Academy of Engineering 2019-XZ-42National Key Research and Development Program of China 2016YFC0901200National Key Research and Development Program of China 2018YFC1311800National Natural Science Foundation of China 82270896Noncommunicable Chronic Diseases-National Science and Technology Major Project 2023ZD0508100Shanghai Medical and Health Development Foundation DMRFP_II_01The Leader Project of the Oriental Talent Program in 2022 No.153
6 · The paper itself

Abstract

backgroundTo determine the associations between sleep phenotypes and the risks of specific obesity types and weight gain in patients with type 2 diabetes (T2D), especially in different genetic risk groups. MATERIALS AND

methodsWe conducted a prospective study involving 58 890 participants. Sleep and napping were assessed according to the standardized questionnaire. General and abdominal obesity were defined by BMI or visceral fat area (VFA), respectively. Multivariable Cox regression, stratified, and joint analysis were performed to explore potential correlations. Furthermore, mediation models were constructed to figure out the mediating role of metabolic factors (blood pressure, UACR, and HbA1c).

resultsDuring a median 3.05-year follow-up period, short sleep increased the risk of obesity (HR 1.42, 95% CI 1.17-1.71; 1.33, 1.08-1.65) and weight gain (1.21, 1.09-1.34; 1.17, 1.06-1.29), while long sleep and napping were unrelated to abdominal obesity and weight gain. Mediation analysis showed that systolic blood pressure, UACR, and HbA1c mediated the statistical association between night sleep duration and general obesity with proportions (%) of 7.9, 1.8, and 8.8, respectively. Joint analysis showed both sleep and napping groups had no significance among the low genetic risk group, while long napping, short sleep, and long sleep increased the risk of general obesity in medium to high risk patients.

conclusionsShort sleep, long sleep, and long napping increased the risk of general obesity and BMI-defined weight gain, and were more pronounced in the medium to high genetic risk group. Napping was unrelated to abdominal obesity. Metabolic factors partially explain the mechanism between sleep and obesity.

Indexed as

Diabetes Mellitus, Type 2Genetic Predisposition to DiseaseObesitySleepAdultAgedBody Mass IndexFemaleFollow-Up StudiesHumansMaleMiddle AgedPhenotypeProspective StudiesRisk FactorsWeight Gaingenetic riskobesitysleeptype 2 diabetesweight gain

Identifiers

PMID40394863
PMCPMC12092374

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