ArticleInterdisciplinary cardiovascular and thoracic surgery2025
Characteristics of calcium deposition on expanded polytetrafluoroethylene membrane as a valve substitute in the pulmonary position.
Article in Interdisciplinary cardiovascular and thoracic surgery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Reduction of Pericardial Adhesions with Polyethylene Glycol Hydrogel Compound, BAX602 in Staged Pediatric Heart Surgery: A Randomized Controlled Trial Protocol.Pediatric cardiology · 2026Article
- Early Biological Reaction to a Synthetic Hybrid Patch Inducing Tissue Ingrowth as a Senning Atrial Baffle.Annals of thoracic surgery short reports · 2026Article
- Current Status and Priorities of Valved Conduits for Right Ventricle-to-Pulmonary Artery Reconstruction in Japan: A Nationwide Survey.Interdisciplinary cardiovascular and thoracic surgery · 2026Article
- Is Reconstructing the Right Ventricle-Pulmonary Artery Continuity Without a Conduit Worthwhile? Reevaluation in the Modern Era.Annals of thoracic surgery short reports · 2026Article
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Authors and funding
6 authors.
Funding
Abstract
An expanded polytetrafluoroethylene membrane has been widely used off-label as a substitute for a pulmonary valve leaflet. However, details regarding the calcification of the membrane in human samples have not been fully described. This report observed the precise extent and distribution of calcification in the membrane. Two samples of calcified expanded polytetrafluoroethylene membranes used as pulmonary valve substitutes were taken at replacement surgery 10 and 15 years after implantation into a valved conduit or transannular patch, respectively. In addition to general histological examination, 3D micro-computed tomography imaging and scanning electron microscopy-backscattered electron imaging were performed to reveal the precise location and extent of calcium deposition in the excised valve leaflets. Along with mineralization across the immobile membrane embedded in calcified pseudointimal tissue, calcium deposits were also detected in micro-interstices of the membrane in areas not covered by calcified fibrous tissue in both specimens. Fluorine properties and specific membrane interstices structure may cause unique calcium deposition independent of the foreign body reactions, leading to transmural calcification with thick pseudointimal embedding.
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